1-(2-噻吩基)-3-(二甲氨基)-1-丙醇合成路线 （共 12 条）
反应条件
sodium tetrahydroborate; sodium hydroxide in methanol; water T=35 - 40°C; 2 h;
参考文献
JUBILANT LIFE SCIENCES LIMITED; BISWAS, Sujay; TRIVEDI, Archana; KHARBANDA, Manlta; DUBEY, Shailendra; SINGLA, Sandeep; YOGIRAJ, Mansukhlal, Bodheka; VIR, Dharam
Patent: WO2011/33366 A2, 2011 ;
Location in patent: Page/Page column 19 ;
反应条件
sodium tetrahydroborate; potassium carbonate in methanol
参考文献
Bioorganic and medicinal chemistry letters, , vol. 13, # 24 p. 4477 - 4480
反应条件
hydrogenchloride in water T=22°C; 7 h;
参考文献
Fujima, Yoshito; Ikunaka, Masaya; Inoue, Toru; Matsumoto, Jun
Organic Process Research and Development, 2006 , vol. 10, # 5 p. 905 - 913
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 8 h; Reflux;
参考文献
Chen, Shao-Rui; Li, Ai-Jun; Chen, Ming-Ming
Asian Journal of Chemistry, 2012 , vol. 24, # 4 p. 1680 - 1684
反应条件
1: aq. HCl / ethanol 2: aq. K2CO3; NaBH4 / methanol View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 13, # 24 p. 4477 - 4480
反应条件
hydrogenchloride in water T=21°C; 2 h;
参考文献
Organic Process Research and Development, , vol. 10, # 5 p. 905 - 913
反应条件
1: N,N-dimethyl-3-(thien-2-yl)-3-hydroxy-propanamine With potassium hydroxide T=20°C; 0.5 h; 2: 4-fluoro-l-naphthalene in water; dimethyl sulfoxide T=90°C; 12 h;
参考文献
Chen, Shao-Rui; Li, Ai-Jun; Chen, Ming-Ming
Asian Journal of Chemistry, 2012 , vol. 24, # 4 p. 1680 - 1684
反应条件
1.1: sodium hydride / dimethyl sulfoxide / 20 °C 1.2: 48 - 50 °C 1.3: 5 h / 20 °C 2.1: sodium hydroxide / toluene; water / 20 - 45 °C / pH 11 - 12 View Scheme
反应条件
1: toluene / 0.5 h / 80 °C 2: sodium hydroxide / water View Scheme
参考文献
Fujima, Yoshito; Ikunaka, Masaya; Inoue, Toru; Matsumoto, Jun
Organic Process Research and Development, 2006 , vol. 10, # 5 p. 905 - 913
反应条件
1: N,N-dimethyl-3-(thien-2-yl)-3-hydroxy-propanamine With sodium hydride in dimethyl sulfoxide T=20°C; 2: 4-fluoro-l-naphthalene in dimethyl sulfoxide T=48 - 50°C; 3: oxalic acid in ethyl acetate T=20°C; 5 h;
参考文献
JUBILANT LIFE SCIENCES LIMITED; BISWAS, Sujay; TRIVEDI, Archana; KHARBANDA, Manlta; DUBEY, Shailendra; SINGLA, Sandeep; YOGIRAJ, Mansukhlal, Bodheka; VIR, Dharam
Patent: WO2011/33366 A2, 2011 ;
Location in patent: Page/Page column 23 ;
