2-硝基-4-(三氟甲基)苯乙腈合成路线 （共 9 条）
反应条件
sulfuric acid in acetic acid Heating;
参考文献
Belley; Scheigetz; Dube; Dolman
Synlett, 2001 , # 2 p. 222 - 225
反应条件
1: 74 percent / K2CO3 / dimethylformamide / 100 °C 2: 67 percent / H2SO4 / acetic acid / Heating View Scheme
参考文献
Kalir,A.; Pelah,Z.
Israel Journal of Chemistry, 1966 , vol. 4, p. 155 - 159
反应条件
potassium tert-butylate in tetrahydrofuran T=-20 - -10°C; 0.5 h; Yield given. Yields of byproduct given;
参考文献
Makosza, Mieczyslaw; Wenaell, Maria; Golinski, Miroslaw; Kinowski, Andrzej
Bulletin of the Polish Academy of Sciences, Chemistry, 1985 , vol. 33, # 9-10 p. 427 - 432
反应条件
potassium tert-butylate in tetrahydrofuran T=-20 - -10°C; 0.00833333 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Makosza, Mieczyslaw; Wenaell, Maria; Golinski, Miroslaw; Kinowski, Andrzej
Bulletin of the Polish Academy of Sciences, Chemistry, 1985 , vol. 33, # 9-10 p. 427 - 432
反应条件
potassium tert-butylate in tetrahydrofuran T=-20 - -10°C; 0.00833333 h; Yield given. Yields of byproduct given;
参考文献
Makosza, Mieczyslaw; Wenaell, Maria; Golinski, Miroslaw; Kinowski, Andrzej
Bulletin of the Polish Academy of Sciences, Chemistry, 1985 , vol. 33, # 9-10 p. 427 - 432
反应条件
1: HNO3, H2SO4 2: K2CO3 / dimethylformamide 3: H2SO4 / aq. acetic acid View Scheme
参考文献
Kalir,A.; Pelah,Z.
Israel Journal of Chemistry, 1966 , vol. 4, p. 155 - 159
反应条件
palladium monocarbide in ethanol; water; acetic acid
参考文献
Mattson, Ronald J.; Denhart, Derek John; Deskus, Jeffrey A.; Ditta, Jonathan L.; Marcin, Lawrence R.; Epperson, James R.; Catt, John D.; King, Dalton; Higgins, Mendi A.
Patent: US2003/73849 A1, 2003 ;
US 20030073849 A1
反应条件
hydrogen; palladium on activated charcoal in ethanol P=3040 Torr;
参考文献
Belley; Scheigetz; Dube; Dolman
Synlett, 2001 , # 2 p. 222 - 225
反应条件
1: With sodium azide; zinc dibromide in water; isopropyl alcohol
48 h; Heating / reflux;
2: With hydrogenchloride in water; isopropyl alcohol
参考文献
GLAXO GROUP LIMTED
Patent: WO2007/14054 A2, 2007 ;
Location in patent: Page/Page column 49 ;
WO 2007/014054 A2
