3-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-甲腈合成路线

24036-52-06-溴-2H-1,4-苯并噁嗪-3(4H)-酮+557-21-1氰化锌→134997-74-33-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-甲腈

参考文献

ALANTOS PHARMACEUTICALS HOLDING, INC.
Patent: WO2008/63671 A2, 2008 ;
Location in patent: Page/Page column 174 ;
WO 2008/063671 A2

14543-43-22-氨基-4-氰基苯酚+598-21-0溴乙酰溴→134997-74-33-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-甲腈

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/134378 A1, 2006 ;
Location in patent: Page/Page column 86 ;
WO 2006/134378 A1

14543-43-22-氨基-4-氰基苯酚+79-04-9一氯代乙酰氯→134997-74-33-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-甲腈

参考文献

Abbott GmbH and Co. KG
Patent: US7049312 B1, 2006 ;
Location in patent: Page/Page column 117 ;
US 7049312 B1

7652-29-16-氯-2H-1,4-苯并噁嗪-3(4H)-酮+544-92-3氰化亚铜→134997-74-33-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-甲腈

参考文献

Alantos Pharmaceuticals, Inc.,
Patent: US2006/173183 A1, 2006 ;
Location in patent: Page/Page column 104 ;

1026273-07-3→134997-74-33-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-甲腈

参考文献

Caliendo, Giuseppe; Perissutti, Elisa; Santagada, Vincenzo; Fiorino, Ferdinando; Severino, Beatrice; Cirillo, Donatella; D'Emmanuele Di Villa Bianca, Roberta; Lippolis, Laura; Pinto, Aldo; Sorrentino, Raffaella
European Journal of Medicinal Chemistry, 2004 , vol. 39, # 10 p. 815 - 826

55197-32-5→134997-74-33-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-甲腈

参考文献

Ackermann, Jean; Bleicher, Konrad; Ceccarelli Grenz, Simona M.; Chomienne, Odile; Mattei, Patrizio; Schulz-Gasch, Tanja
Patent: US2007/129544 A1, 2007 ;
Location in patent: Page/Page column 56 ;

24036-52-06-溴-2H-1,4-苯并噁嗪-3(4H)-酮→134997-74-33-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-甲腈

参考文献

AQUILUS PHARMACEUTICALS, INC.; SUCHOLEIKI, Irving
Patent: WO2014/62204 A1, 2014 ;
Location in patent: Page/Page column 33 ;

14543-43-22-氨基-4-氰基苯酚→134997-74-33-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-甲腈

参考文献

Caliendo, Giuseppe; Grieco, Paolo; Perissutti, Elisa; Santagada, Vincenzo; Santini, Antonello; Albrizio, Stefania; Fattorusso, Caterina; Pinto, Aldo; Sorrentino, Raffaella
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 12 p. 957 - 967

3272-08-04-羟基-3-硝基苯甲腈→134997-74-33-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-甲腈

参考文献

Caliendo, Giuseppe; Grieco, Paolo; Perissutti, Elisa; Santagada, Vincenzo; Santini, Antonello; Albrizio, Stefania; Fattorusso, Caterina; Pinto, Aldo; Sorrentino, Raffaella
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 12 p. 957 - 967

7652-29-16-氯-2H-1,4-苯并噁嗪-3(4H)-酮→134997-74-33-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-甲腈

参考文献

Gege, Christian; Bao, Bagna; Bluhm, Harald; Boer, Juergen; Gallagher, Brian M.; Korniski, Brian; Powers, Timothy S.; Steeneck, Christoph; Taveras, Arthur G.; Baragi, Vijaykumar M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 709 - 716