2-三甲基硅基-1,3-二噻吩合成路线 （共 37 条）
反应条件
n-butyllithium
1.) THF, pentane, -50 deg C, 1 h, 2.) -20 deg C, 2 h; 25 deg C, overnight; Yield given. Multistep reaction;
参考文献
Li, Chuen; Sammes, Michael P.; Harlow, Richrd L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 1299 - 1302
反应条件
1: 2-(trimethylsilyl)-1,3-dithiane With cyclohexane; sec.-butyllithium in tetrahydrofuran; hexane
T=-70 - 0°C; Inert atmosphere;
2: 4-ketocyclohexanecarboxylic acid ethyl ester in tetrahydrofuran; hexane
T=-70 - 20°C; 6 h; Inert atmosphere;
参考文献
JNC Corporation; JNC Petrochemical Corporation; MASUKAWA, Tokifumi
Patent: EP2690103 A1, 2014 ;
Location in patent: Paragraph 0333 ;
反应条件
n-butyllithium
1) Et2O, 0 deg C, 45 min, 2) Et2O, 0 deg C, 2 to 3 h; Yield given. Multistep reaction;
参考文献
Muzard; Portella
Synthesis, 1992 , # 10 p. 965 - 968
反应条件
1: 2-(trimethylsilyl)-1,3-dithiane With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C; Peterson olefination;
2: pentanal in tetrahydrofuran; hexane
T=20°C; 20 h;
参考文献
Aggarwal, Varinder K.; Steele, Rebecca M.; Ritmaleni; Barrell, Juliet K.; Grayson, Ian
Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 4087 - 4090
反应条件
1: 2-(trimethylsilyl)-1,3-dithiane With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C;
2: acetaldehyde in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Murakami, Kei; Imoto, Junichi; Matsubara, Hiroshi; Yoshida, Suguru; Yorimitsu, Hideki; Oshima, Koichiro
Chemistry - A European Journal, 2013 , vol. 19, # 18 p. 5625 - 5630
反应条件
1: 2-(trimethylsilyl)-1,3-dithiane With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C; Peterson olefination; 5 h;
2: cyclohexanone in tetrahydrofuran; hexane
T=-78 - 20°C; 47 h;
参考文献
Aggarwal, Varinder K.; Steele, Rebecca M.; Ritmaleni; Barrell, Juliet K.; Grayson, Ian
Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 4087 - 4090
反应条件
n-butyllithium
1.) THF, hexane, -40 deg C, 2 h 2.) THF, -78 deg C; Yield given. Multistep reaction;
参考文献
Page, Philip C. Bulman; Harkin, Shaun A; Marchington, Allan P.; Niel, Monique B. van
Tetrahedron, 1989 , vol. 45, # 12 p. 3819 - 3838
