(S)-3-[(甲基磺酰基)氧基]吡咯烷-1-羧酸叔丁酯合成路线 （共 16 条）
反应条件
in N,N-dimethyl-formamide T=100°C; 18 h; Inert atmosphere;
参考文献
GLAXOSMITHKLINE LLC; DOCK, Steven, Thomas; MCSHERRY, Allison, K.; MOORE, Michael, Lee; RIDGERS, Lance, Howard; PARRISH, Cynthia, Ann
Patent: WO2013/28445 A1, 2013 ;
Location in patent: Page/Page column 51 ;
反应条件
in dimethyl sulfoxide T=80°C; 4 h;
参考文献
ASTRAZENECA AB; ASTRAZENEKA UK LIMITED
Patent: WO2005/26156 A1, 2005 ;
Location in patent: Page/Page column 117 ;
WO 2005/026156 A1
反应条件
in dimethyl sulfoxide; ethyl acetate; pentane
参考文献
PFIZER INC.; Pfizer Limited
Patent: EP997474 A1, 2000 ;
反应条件
in N,N-dimethyl-formamide Substitution;
参考文献
Kim, Yong Jip; Kaiser, Donald A.; Pollard, Thomas D.; Ichikawa, Yoshitaka
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 21 p. 2417 - 2419
反应条件
1: dimethylformamide 2: NH3 / methanol View Scheme
参考文献
Kocalka, Petr; Pohl, Radek; Rejman, Dominik; Rosenberg, Ivan
Tetrahedron, 2006 , vol. 62, # 24 p. 5763 - 5774
反应条件
1: N,N-dimethyl-formamide / 100 °C / Inert atmosphere 2: triethylamine; hydrogen / ethanol / 20 °C / 2585.81 - 3102.97 Torr / Inert atmosphere View Scheme
参考文献
GLAXOSMITHKLINE LLC; CHAUDHARI, Amita, M.; HALLMAN, Jason; LAUDEMAN, Christopher, P.; MUSSO, David, Lee; PARRISH, Cynthia, A.
Patent: WO2011/66211 A1, 2011 ;
WO 2011/066211 A1
