4-[[[(1,1-二甲基乙基)二甲基硅烷基]氧基]甲基]苯胺合成路线 （共 8 条）
反应条件
hydrogen; 5percent Pd/C in tetrahydrofuran T=20°C; Catalytic hydrogenation;
参考文献
Luo; Guldi; Imahori; Tamaki; Sakata
Journal of the American Chemical Society, 2000 , vol. 122, # 28 p. 6535 - 6551
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in N,N-dimethyl-formamide T=20°C;
参考文献
ABBOTT LABORATORIES
Patent: WO2009/11850 A2, 2009 ;
Location in patent: Page/Page column 151-152 ;
WO 2009/011850 A2
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; tris(dibenzylideneacetone)dipalladium (0); Ti-N complexes; sodium t-butanolate in toluene T=90°C; 4 h;
参考文献
Hori; Mori
Journal of the American Chemical Society, 1998 , vol. 120, # 30 p. 7651 - 7652
反应条件
1: 98 percent / imidazole / dimethylformamide / 2 h / 20 °C 2: 84 percent / ammonium formate / Pd/C / ethanol / 5 h / 20 °C View Scheme
参考文献
Shiraishi, Mitsuru; Aramaki, Yoshio; Seto, Masaki; Imoto, Hiroshi; Nishikawa, Youichi; Kanzaki, Naoyuki; Okamoto, Mika; Sawada, Hidekazu; Nishimura, Osamu; Baba, Masanori; Fujino, Masahiko
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2049 - 2063
反应条件
1: 100 percent / imidazole / dimethylformamide / 2.5 h / 20 °C 2: 100 percent / H2 / 5percent Pd/C / tetrahydrofuran / 20 °C View Scheme
参考文献
El Alaoui, Abdessamad; Schmidt, Frederic; Monneret, Claude; Florent, Jean-Claude
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9628 - 9636
反应条件
1: iPr2NEt; HATU / dimethylformamide / 18 h / 20 °C
2: 100 mg / TBAF / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
triethylamine in toluene
T=70°C; 3 h;
参考文献
El Alaoui, Abdessamad; Schmidt, Frederic; Monneret, Claude; Florent, Jean-Claude
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9628 - 9636
参考文献
Erez, Rotem; Shabat, Doron
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 15 p. 2669 - 2672
