(四氢吡喃-4-亚基)乙酸乙酯合成路线 （共 18 条）
反应条件
sodium hydride in mineral oil; benzene T=0 - 20°C; 2.33333 h; Inert atmosphere;
参考文献
WO2013/37960 A1, ;
Page/Page column 75 ;
反应条件
in acetonitrile T=20 - 70°C; 16 h;
参考文献
US2011/144105 A1, ;
Page/Page column 54 ;
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in DMF (N,N-dimethyl-formamide) T=0°C; 0.833333 h; 2: tetrahydro-pyran-4-one in DMF (N,N-dimethyl-formamide) T=0°C; 0.583333 h;
参考文献
EP1443046 A1, ;
Page 183 ;
EP 1443046 A1
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in ethylene glycol dimethyl ether T=20 - 25°C; 0.75 h; 2: tetrahydro-pyran-4-one
参考文献
EP1019398 B1, ;
Page 43 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C;
参考文献
US6340691 B1, ;
Page column 66 ;
US 6340691 B1
反应条件
Fe(TCP)Cl; polyethylene supported arsine; polymethylhydrosiloxane in toluene T=110°C; Wittig type reaction; 12 h; Inert atmosphere;
参考文献
Chemical Communications, , vol. 48, # 2 p. 290 - 292
反应条件
1: 98.5 percent / hydrogen / Pd/C / ethanol / 2585.74 Torr 2: 100 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Prelog et al.
Justus Liebigs Annalen der Chemie, 1937 , vol. 532, p. 80
Chem.Abstr., 1940 , p. 4396
反应条件
1: 98.5 percent / hydrogen / Pd/C / ethanol / 2585.74 Torr 2: 100 percent / LiAlH4 / tetrahydrofuran / Heating 3: 77 percent / Et3N / CH2Cl2 / 16 h / 0 - 20 °C 4: 73 percent / LiBr / acetone / 5 h / Heating View Scheme
参考文献
LABORATORIOS DEL DR. ESTEVE, S.A.; DRACONIS PHARMA, S.L.; ALMIRALL, S.A.; TORRENS JOVER, Andoni; MERCÈ VIDAL, Ramon; CALDENTEY FRONTERA, Francesc Xavier; RODRÍGUEZ GARRIDO, Antonio, David; CARCELLER GONZÁLEZ, Elena; SALAS SOLANA, Jordi
Patent: WO2013/37960 A1, 2013 ;
反应条件
1: 1.8 g / H2 / 10percent Pd/C / ethanol / 240 h / 760 Torr 2: 1.1 g / 10percent aq. NaOH / ethanol / 4 h View Scheme
参考文献
Meiji Seika Pharma Co., Ltd.; MORINAKA, Akihiro; MAEBASHI, Kazunori; IDA, Takashi; HIKIDA, Muneo; YAMADA, Mototsugu; ABE, Takao
Patent: EP2737900 A1, 2014 ;
