(i) LDA, THF, (ii) /BRN= 635680/; Multistep reaction;

sodium methylate

in benzene T=65°C; 3 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3620030', constants.ctx, '0')">tetramethyl-ammonium iodide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8128173', constants.ctx, '0')">palladium dichloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '106420', constants.ctx, '0')">1-methyl-pyrrolidin-2-one</a> <br />T=20 - 240&deg;C;&nbsp;P=7500.75 - 48754.9&nbsp;Torr;&nbsp;1.96667&nbsp;h;&nbsp;&nbsp;Autoclave;&nbsp;&nbsp;Product distribution / selectivity;&nbsp;<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3620030', constants.ctx, '0')">tetramethyl-ammonium iodide</a>;&nbsp;H₂IrCl₃&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '106420', constants.ctx, '0')">1-methyl-pyrrolidin-2-one</a> <br />T=20 - 240&deg;C;&nbsp;P=7500.75 - 48754.9&nbsp;Torr;&nbsp;3.18333&nbsp;h;&nbsp;&nbsp;Autoclave;&nbsp;&nbsp;Product distribution / selectivity;&nbsp;<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3620030', constants.ctx, '0')">tetramethyl-ammonium iodide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8128173', constants.ctx, '0')">palladium dichloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '106420', constants.ctx, '0')">1-methyl-pyrrolidin-2-one</a> <br />T=20 - 240&deg;C;&nbsp;P=7500.75 - 48754.9&nbsp;Torr;&nbsp;2.16667&nbsp;h;&nbsp;&nbsp;Autoclave;&nbsp;&nbsp;Product distribution / selectivity;&nbsp;<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '113089', constants.ctx, '0')">[2,2']bipyridinyl</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8128173', constants.ctx, '0')">palladium dichloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '106420', constants.ctx, '0')">1-methyl-pyrrolidin-2-one</a> <br />T=20 - 200&deg;C;&nbsp;P=22502.3&nbsp;Torr;&nbsp;8&nbsp;h;&nbsp;&nbsp;Autoclave;&nbsp;&nbsp;Reagent/catalystTime;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342937', constants.ctx, '0')">potassium hydroxide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '14497211', constants.ctx, '0')">air</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />T=20&deg;C;&nbsp;30&nbsp;h;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342937', constants.ctx, '0')">potassium hydroxide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '14497211', constants.ctx, '0')">air</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />T=20&deg;C;&nbsp;90&nbsp;h;&nbsp;<br /> &nbsp;