1: KOH / ethanol; H2O / 0.5 h / Heating 2: conc. aq. HCl / 5.5 h / Heating View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 1,2-dichloro-ethane / 52 &deg;C / also other temperatures (40.0 and 64.4 deg C); activation energy<br />2: 58 percent / potassium tert-butoxide / dimethylsulfoxide / 0.5 h<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3556712', constants.ctx, '0')">potassium <i>tert</i>-butylate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '506008', constants.ctx, '0')">dimethyl sulfoxide</a> <br />0.5&nbsp;h;&nbsp;<br /> &nbsp;