2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
1.1: hydrogen bromide / 1 h / 110 °C 1.2: 11 h / 110 °C 2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 25 °C / Inert atmosphere View Scheme
参考文献
Principia Biopharma Inc.; Goldstein, David Michael
Patent: US8673925 B1, 2014 ;
反应条件
pyridine; bromine; triphenylphosphine in chloroform 12 h; Ambient temperature;
参考文献
Dale, Johannes; Fredriksen, Siw B.
Acta Chemica Scandinavica, 1991 , vol. 45, # 1 p. 82 - 91
反应条件
lithium hydroxide; hydrogen bromide; acetic acid 1.) reflux, 8 h, 2.) water, DME, 3 h; Yield given. Multistep reaction;
参考文献
Hua, Duy H.; Venkataraman, S.; Ostrander, Robert A.; Sinai, Gurudas-Z.; McCann, Peggy J.; et al.
Journal of Organic Chemistry, 1988 , vol. 53, # 3 p. 507 - 515
反应条件
hydrogen bromide 8 h; Heating; Title compound not separated from byproducts;
参考文献
Hua, Duy H.; Venkataraman, S.; Ostrander, Robert A.; Sinai, Gurudas-Z.; McCann, Peggy J.; et al.
Journal of Organic Chemistry, 1988 , vol. 53, # 3 p. 507 - 515
参考文献
Franke
Monatshefte fuer Chemie, 1913 , vol. 34, p. 1904
参考文献
Kristensen, Jesper; Lysen, Morten; Vedso, Per; Begtrup, Mikael
Organic Letters, 2001 , vol. 3, # 10 p. 1435 - 1437
参考文献
Kristensen, Jesper; Lysen, Morten; Vedso, Per; Begtrup, Mikael
Organic Letters, 2001 , vol. 3, # 10 p. 1435 - 1437
参考文献
Tobisu, Mamoru; Shimasaki, Toshiaki; Chatani, Naoto
Angewandte Chemie - International Edition, 2008 , vol. 47, # 26 p. 4866 - 4869
反应条件
bromine; triphenylphosphine in acetonitrile T=0 - 80°C;
参考文献
Wu, Yong; Shi, Chen; Sun, Xiaowei; Wu, Xiaoming; Sun, Hongbin
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 14 p. 4238 - 4249
参考文献
Franke
Monatshefte fuer Chemie, 1913 , vol. 34, p. 1904
