2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
1: tri-isopropoxy-borane; alpha,alpha,alpha-trifluoro-m-toluonitrile With 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; hexane
T=-78 - 20°C;
2: 3-hydroxy-2,2-dimethylpropanol in tetrahydrofuran; hexane
T=20°C; 1 h;
参考文献
Lysen, Morten; Hansen, Henriette M.; Begtrup, Mikael; Kristensen, Jesper L.
Journal of Organic Chemistry, 2006 , vol. 71, # 6 p. 2518 - 2520
参考文献
Majoral,J.-P.; Navech,J.
Bulletin de la Societe Chimique de France, 1971 , p. 95 - 104
反应条件
2: N2O4 / CH2Cl2 / -60 °C
View Scheme
参考文献
McConnell; Coover
Journal of Organic Chemistry, 1959 , vol. 24, p. 630,634
反应条件
1: 1H-tetrazole / toluene; acetonitrile / 20 °C
2: 229 mg / Me3SiI; benzene / 72 h / 60 °C
View Scheme
参考文献
Singh,G.
Journal of Organic Chemistry, 1979 , vol. 44, p. 1060 - 1063
参考文献
Major et al.
Journal of Organic Chemistry, 1959 , vol. 24, p. 431
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Du Pont de Nemours and Co.
Patent: US2787630 , 1954 ;
反应条件
1: tri-isopropoxy-borane; 2-methoxy 5-cyanobenzene; lithium diisopropyl amide
2: 3-hydroxy-2,2-dimethylpropanol Title compound not separated from byproducts;
参考文献
Lysen, Morten; Hansen, Henriette M.; Begtrup, Mikael; Kristensen, Jesper L.
Journal of Organic Chemistry, 2006 , vol. 71, # 6 p. 2518 - 2520
反应条件
Envirocat EPZG in toluene
2 h; Heating;
参考文献
Bandgar, Babasaheb P.; Gaikwad, Nandkumar B.
Monatshefte fur Chemie, 1998 , vol. 129, # 6-7 p. 719 - 722
反应条件
hydrogenchloride
T=98°C;
参考文献
Larionov, V. I.; Lapuka, L. F.; Musavirov, R. S.; Zlot-skii, S. S.; Rakhmankulov, D. L.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 10 p. 2280 - 2284,2030 - 2033
反应条件
hydrogenchloride
T=83°C;
参考文献
Larionov, V. I.; Lapuka, L. F.; Musavirov, R. S.; Zlot-skii, S. S.; Rakhmankulov, D. L.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 10 p. 2280 - 2284,2030 - 2033
反应条件
sodium hydride in tetrahydrofuran
T=20°C; 3 h;
参考文献
Liu, Degang; Xue, Jijun; Xie, Zhixiang; Wei, Liping; Zhang, Xianshu; Li, Ying
Synlett, 2008 , # 10 p. 1526 - 1528
