2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
1: TsOH*H2O / benzene / Heating
2: DIBAL / CH2Cl2
View Scheme
参考文献
Takano, Seiichi; Akiyama, Masashi; Sato, Seiji; Ogasawara, Kunio
Chemistry Letters, 1983 , p. 1593 - 1596
反应条件
toluene-4-sulfonic acid in benzene
18 h; Heating;
参考文献
Plieger, Paul G.; Burrell, Anthony K.; Jameson, Geoffrey B.; Officer, David L.
Dalton Transactions, 2004 , # 2 p. 319 - 326
参考文献
Ueno, Satoshi; Chatani, Naoto; Kakiuchi, Fumitoshi
Journal of the American Chemical Society, 2007 , vol. 129, # 19 p. 6098 - 6099
反应条件
1: 3-hydroxy-2,2-dimethylpropanol With tetrakis(dimethylamino)diboron; potassium acetate in tetrahydrofuran
T=80°C; 0.5 h;
2: 1-bromo-2-methyl-1-propene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=80°C; 24 h;
参考文献
BASF SE; SCHMIDT-LEITHOFF, Joachim; PICHLMAIR, Stefan; BELLO, Charles; BASF (CHINA) COMPANY LIMITED
Patent: WO2013/14579 A1, 2013 ;
Location in patent: Page/Page column 15 ;
参考文献
Ueno, Satoshi; Chatani, Naoto; Kakiuchi, Fumitoshi
Journal of the American Chemical Society, 2007 , vol. 129, # 19 p. 6098 - 6099
反应条件
1: potassium acetate / 80 °C
2: tetrakis(triphenylphosphine) palladium(0) / toluene / 24 h / 80 °C
View Scheme
参考文献
Bello, Charles S.; Schmidt-Leithoff, Joachim
Tetrahedron Letters, 2012 , vol. 53, # 46 p. 6230 - 6235,6
反应条件
lithium aluminium tetrahydride; pyridinium p-toluenesulfonate
1.) CH2Cl2, reflux, 72 h; 2.) ether, reflux, 6 h; Yield given. Multistep reaction;
参考文献
Bach, Thorsten
Liebigs Annalen, 1995 , # 5 p. 855 - 866
反应条件
potassium hydroxide; dimethyl sulfoxide
T=100°C; P=760 Torr; 5 h;
参考文献
Trofimov, B. A.; Kudyakova, R. N.; Oparina, L. A.; Parshina, L. N.; Vins, V. V.
J. Appl. Chem. USSR (Engl. Transl.), 1991 , vol. 64, # 4.2 p. 873 - 877,786 - 790
反应条件
toluene-4-sulfonic acid in benzene
Heating;
参考文献
Lee, Albert W. M.
Journal of the Chemical Society, Chemical Communications, 1984 , # 9 p. 578 - 579
反应条件
sodium hydroxide
1.) THF, 66 deg C, 1 h, 2.) 66 deg C, 24 h; Yield given. Multistep reaction;
参考文献
Ouchi, Mikio; Inoue, Yoshihisa; Sakamoto, Hidefumi; Yamahira, Atsushi; Yoshinaga, Masanobu; Hakushi, Tadao
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3168 - 3173
