[2-丁基-4-氯-1-[(2’-(1-三苯甲基-1H-四氮唑-5-基)联苯-4-基)甲基)-1H-咪唑-5-基)甲醇合成路线 （共 18 条）
反应条件
1: 2-butyl-4-chloro-1H-imidazole-5-carbaldehyde With sodium hydroxide; tetrabutylammomium bromide in water; toluene T=30 - 35°C; 0.333333 - 0.5 h; 2: [2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl bromide in water; toluene 33 - 35 h;
参考文献
US2004/97568 A1, ;
Page/Page column 5 ;
反应条件
sodium hydroxide; sodium tetrahydroborate in water; toluene
参考文献
US5128355 A1, ;
US 5128355 A
反应条件
1: With potassium carbonate in N,N-dimethyl acetamide T=0 - 20°C; 2: With sodium tetrahydroborate in N,N-dimethyl acetamide; water T=20°C; 3 h;
参考文献
WO2004/66997 A2, ;
Page/Page column 46-47 ;
反应条件
triethylamine in dichloromethane; water
参考文献
US5298517 A1, ;
US 5298517 A
反应条件
triethylamine in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 54, # 12 p. 754 - 757
反应条件
potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran 72 h; Heating / reflux; Product distribution / selectivity;
参考文献
EP1833801 B1, ;
Page/Page column 14 ;
反应条件
1: With sodium tetrahydroborate in n-butyl chloride T=25 - 45°C; 2: With methanol in n-butyl chloride T=40 - 45°C; 5.75 h; 3: With water in n-butyl chloride T=40 - 45°C;
参考文献
WO2006/38223 A1, ;
Page/Page column 6-7 ;
反应条件
potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in water; N,N-dimethyl-formamide; toluene 48 h; Heating / reflux; Product distribution / selectivity;
参考文献
EP1833801 B1, ;
Page/Page column 14 ;
反应条件
1: With cerium(III) chloride in dichloromethane; water 0.0333333 h; 2: With sodium hypochlorite in dichloromethane; water 0.166667 h;
参考文献
WO2006/81807 A2, ;
Page/Page column 16; 18; 20; 28-29 ;
反应条件
1: With hydroxylamine hydrochloride in methanol; water; acetone T=20°C; 2 h; 2: With sodium hydroxide in methanol; water; acetone T=20 - 25°C; pH=3.8 - 4.2;
参考文献
ULKAR KIMYA SANAYII VE TICARET AS
Patent: WO2006/98705 A1, 2006 ;
Location in patent: Page/Page column 10-11 ;
