3,16alpha-二羟基雌甾-1,3,5(10)-三烯-17-酮3,16-二乙酸酯合成路线 （共 6 条）
参考文献
Engelfried; Gibian; Neumann; Prezewowsky; Schulz; Wiechert
Arzneimittel-Forschung, 1966 , vol. 16, # 11 p. 1518 - 1522
参考文献
Engelfried; Gibian; Neumann; Prezewowsky; Schulz; Wiechert
Arzneimittel-Forschung, 1966 , vol. 16, # 11 p. 1518 - 1522
反应条件
1: 560 mg / CrO3 / acetic acid; H2O / 1) 4 deg C, 30 min, 2) r.t., overnight 2: 290 mg / BF3-etherate / acetic acid / Ambient temperature 3: 1.4 g / HgCl2, CaCO3 / acetonitrile; H2O / 0.5 h / Ambient temperature 4: 140 mg / NaBH4 / tetrahydrofuran; methanol; H2O / 0.5 h / 0 °C 5: 11 mg / conc. HCl / methanol / 2 h / 60 °C 6: 21 mg / HgCl2, CaCO3 / acetonitrile; H2O / Heating 7: 4 mg / H2 / 10percent Pd/C / ethyl acetate / 4 h / Ambient temperature View Scheme
参考文献
Ikegawa; Fishman
Steroids, 1982 , vol. 39, # 5 p. 557 - 567
反应条件
lithium aluminium tetrahydride; diethyl ether; benzene
参考文献
Leeds et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 2943,2947
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Biggerstaff; Gallagher
Journal of Organic Chemistry, 1957 , vol. 22, p. 1220
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Biggerstaff; Gallagher
Journal of Organic Chemistry, 1957 , vol. 22, p. 1220
