1,4-二氧杂螺[4.5]癸烷-8-乙腈合成路线 （共 6 条）
反应条件
1: 1.) NaH / 1.) DME, 0 deg C, 1 h, 2.) DME, r.t., 3 h 2: 91 percent / H2 / 5percent Pd/C / methanol View Scheme
参考文献
Yamamoto, Takayoshi; Eki, Toshiko; Nagumo, Shinji; Suemune, Hiroshi; Sakai, Kiyoshi
Tetrahedron, 1992 , vol. 48, # 22 p. 4517 - 4524
反应条件
1: Et3N / CH2Cl2 / 2 h / 0 °C 2: dimethylsulfoxide / 3 h / Heating View Scheme
参考文献
King, Frank D.; Hadley, Michael S.; Joiner, Karen T.; Martin, Roger T.; Sanger, Gareth J.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 683 - 689
反应条件
1: 90 percent / LAH / diethyl ether / 5 h / Ambient temperature 2: Et3N / CH2Cl2 / 2 h / 0 °C 3: dimethylsulfoxide / 3 h / Heating View Scheme
参考文献
King, Frank D.; Hadley, Michael S.; Joiner, Karen T.; Martin, Roger T.; Sanger, Gareth J.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 683 - 689
反应条件
in dimethyl sulfoxide 3 h; Heating;
参考文献
King, Frank D.; Hadley, Michael S.; Joiner, Karen T.; Martin, Roger T.; Sanger, Gareth J.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 683 - 689
反应条件
lithium aluminium tetrahydride in diethyl ether 2 h; Ambient temperature; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 6 p. 683 - 689
反应条件
1: tetrahydrofuran; diethyl ether / 1 h / 0 °C
2: 3percent aq. H2SO4 / acetone
View Scheme
参考文献
Yamamoto, Takayoshi; Eki, Toshiko; Nagumo, Shinji; Suemune, Hiroshi; Sakai, Kiyoshi
Tetrahedron, 1992 , vol. 48, # 22 p. 4517 - 4524
