反应条件
1: N-Boc-3,4-dimethoxylaniline With n-butyllithium in tetrahydrofuran T=-78 - -10°C; 2 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran T=20°C; Inert atmosphere; 3: With hydrogenchloride in tetrahydrofuran; water pH=1 - 2; Inert atmosphere;
参考文献
GLAXO GROUP LIMITED; SHIONOGI and CO., LTD.; LIAO, Xiangmin; PEARSON, Neil, David; PENDRAK, Israil; SANO, Masayuki
Patent: WO2013/52568 A1, 2013 ;
Location in patent: Page/Page column 192 ;
