5-羟甲基异噁唑-3-甲酸乙酯合成路线 （共 14 条）
反应条件
4 A molecular sieve in dichloromethane T=20 - 35°C; 4 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 27, # 6 p. 581 - 593
反应条件
1,4-diaza-bicyclo[2.2.2]octane in ethanol; chloroform T=80°C; 72 h;
参考文献
European Journal of Organic Chemistry, , # 26 p. 4352 - 4359
反应条件
triethylamine in diethyl ether
参考文献
US6200975 B1, ;
US 6200975 B1
反应条件
triethylamine in tetrahydrofuran T=0 - 20°C;
参考文献
WO2005/68432 A1, ;
Page/Page column 221 ;
反应条件
triethylamine in diethyl ether T=20°C; 5 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 1 p. 231 - 234
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 4 p. 872 - 875
反应条件
1: 10percent aq. NaOH / ethanol / Ambient temperature 2: conc. H2SO4 / acetic acid 3: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h 4: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature 5: 75 percent / Et3N / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: 10percent aq. NaOH / ethanol / Ambient temperature 2: conc. H2SO4 / acetic acid 3: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: With water; sodium hydroxide T=20°C; 3.5 h; 2: With hydrogenchloride in water pH=2;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN Randamp;;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick
Patent: WO2010/142801 A1, 2010 ;
Location in patent: Page/Page column 147 ;
WO 2010/142801 A1
反应条件
1: 10percent aq. NaOH / ethanol / Ambient temperature 2: conc. H2SO4 / acetic acid 3: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h 4: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
