2,3,4,5-四氢-5-甲基-1H-吡啶并[4,3-b]吲哚-1-酮合成路线 (共 7 条)
反应条件
1: 3,4-dihydro-2H-pyrido[4,3-b]indol-1(5H)-one With sodium hexamethyldisilazane in N,N-dimethyl-formamide T=5°C; 0.333333 h; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide T=5°C; 0.333333 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/113478 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
sodium hydroxide in water
参考文献
US5196534 A1, ;
US 5196534 A
反应条件
sodium hydroxide in water; acetone
参考文献
US5196534 A1, ;
US 5196534 A
反应条件
hydrogenchloride in ethylene glycol dimethyl ether; water
参考文献
GLAXO GROUP LIMITED
Patent: EP357416 A3, 1990 ;
EP 0357416 A2
反应条件
in 1-methyl-pyrrolidin-2-one T=140°C; 4 h; Inert atmosphere;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/113478 A1, 2010 ;
Location in patent: Page/Page column 13 ;
反应条件
1: With trifluoroacetic acid in N,N-dimethyl-formamide T=100 - 115°C; 2: With potassium carbonate in water pH=6.8 - 7; Product distribution / selectivity;
参考文献
ORCHID CHEMICALS and PHARMACEUTICALS LIMITED
Patent: US2012/178937 A1, 2012 ;
Location in patent: Page/Page column 3 ;
反应条件
p-toluenesulfonic acid monohydrate in 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane
参考文献
Glaxo Group Limited
Patent: US5276050 A1, 1994 ;