3-氨基-4-氯三氟甲苯合成路线 （共 32 条）
反应条件
potassium fluoride; ammonia in 1-methyl-pyrrolidin-2-one T=245 - 250°C; P=22067.2 - 29422.9 Torr; 10 h; Autoclave;
参考文献
WO2011/107998 A1, ;
Page/Page column 17 ;
反应条件
hydrogen; nickel in ethanol T=50°C; P=3750.38 Torr; 5 h;
参考文献
US6410737 B1, ;
Page column 8 ;
反应条件
aluminum oxide; sodium hydrogensulfide 0.0666667 h; microwave irradiation;
参考文献
Synthetic Communications, , vol. 32, # 18 p. 2849 - 2853
反应条件
sodium hydroxide; palladium dichloride in anhydrous xylene
反应条件
carbon monoxide; hexasulfonated 2,2'-bis-diphenylphosphinomethylene binaphthyl; palladium dichloride in water; xylene T=100°C; P=90007.2 Torr; 20 h; Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 36, # 51 p. 9305 - 9308
反应条件
hydrogenchloride; iron
参考文献
Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), , vol. 28, p. 969,972
Chem.Abstr., , p. 4880
Nippon Kagaku Zasshi, , vol. 79, p. 889,892
Chem.Abstr., , p. 4430
反应条件
sulfuric acid; sodium nitrite anschliessendes Erwaermen mit wss. H2SO4 unter Einleiten von Wasserdampf;
参考文献
Journal of the American Chemical Society, , vol. 73, p. 3470
反应条件
1: 1-amino-2-chloro-5-trifluoromethylbenzene With sulfuric acid in water T=15°C; Sandmeyer Reaction; 0.5 h; Large scale; 2: With sodium nitrite in water; toluene T=3°C; Sandmeyer Reaction; 0.75 h; Large scale; 3: copper (I) cyanide With sodium cyanide; sodium carbonate in n-heptane; water T=65°C; Sandmeyer Reaction; 2 h; Large scale; Temperature;
参考文献
Organic Process Research and Development, , vol. 8, # 6 p. 1059 - 1064
反应条件
(i) NaNO2, H2SO4, (ii) aq. ZnCl2, (iii) /BRN= 3587243/, CuCN, aq. NaHCO3, PE; Multistep reaction;
参考文献
Helvetica Chimica Acta, , vol. 45, p. 2226 - 2241
反应条件
triethylamine in acetone T=0 - 20°C;
参考文献
Zhang, Shulan; Zhao, Yanfang; Liu, Yajing; Chen, Dong; Lan, Weihuan; Zhao, Qiaoling; Dong, Chengcheng; Xia, Lin; Gong, Ping
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 8 p. 3504 - 3510
