4-氯-3-硝基三氟甲苯合成路线 （共 136 条）
参考文献
Frazier,T.C. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2223 - 2225
反应条件
sodium hydroxide; tetrabutylammomium bromide in water; toluene
T=40°C; various amines under different reaction conditions; Product distributionRate constant;
参考文献
Durantini, Edgardo N.; Chiacchiera, Stella M.; Silber, Juana J.
Synthetic Communications, 1996 , vol. 26, # 20 p. 3849 - 3858
反应条件
18-crown-6 ether; trichloroacetic acid methyl ester; potassium carbonate
T=150°C; 2 h;
参考文献
Renga, James M.; Wang, Pen-Chung
Synthetic Communications, 1984 , vol. 14, # 1 p. 69 - 76
反应条件
1: potassium tert-butylate / tert-butyl alcohol / Reflux
2: dimethyl sulfoxide; sodium chloride / water / 120 °C
3: hydrogen / 5 Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr
4: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice
View Scheme
参考文献
UNIVERSITY OF KANSAS; GEORGE, Ingrid, Gunda; TASH, Joseph, S.; CHAKRSALI, Ramappa; JAKKARAJ, Sudhakar, R.; CALVET, James, P.
Patent: WO2011/5759 A2, 2011 ;
反应条件
potassium carbonate in ethanol
参考文献
BASF Aktiengesellschaft
Patent: US5714489 A1, 1998 ;
反应条件
sodium ethanolate in ethanol
4 h; Heating;
参考文献
Della Vecchia; Dellureficio; Kisis; Vlattas
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 5 p. 1287 - 1294
反应条件
1: 91 percent / NaOC2H5 / ethanol / 4 h / Heating
2: 84.3 percent / Sn, conc.HCl / ethanol / 0.5 h / steam bath
View Scheme
参考文献
Della Vecchia; Dellureficio; Kisis; Vlattas
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 5 p. 1287 - 1294
反应条件
potassium carbonate in dimethyl sulfoxide
T=100°C; 3 h;
参考文献
Corral; Lissavetzky; Valdeolmillos
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 5 p. 1349 - 1352
反应条件
1: 91 percent / K2CO3; Pd(PPh3)4 / toluene; H2O / 4 h / Heating
2: 85 percent / PPh3 / 1,2-dichloro-benzene / 6 h / Heating
View Scheme
参考文献
Freeman, Adam W.; Urvoy, Marie; Criswell, Megan E.
Journal of Organic Chemistry, 2005 , vol. 70, # 13 p. 5014 - 5019
反应条件
1: 68 percent / K2CO3 / dimethylformamide / 0.5 h / 110 - 115 °C
2: 83 percent / Fe; AcOH / ethanol / 0.5 h / Heating
View Scheme
参考文献
Zarudnitskii, Evgenij V.; Ivanov, Vladimir V.; Yurchenko, Alexandr A.; Pinchuk, Alexandr M.; Tolmachev, Andrej A.
Heteroatom Chemistry, 2002 , vol. 13, # 2 p. 146 - 152
