2-[(4-乙氧基-1,4-二氧代丁基)氨基]苯甲酸乙酯合成路线 （共 5 条）
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
BIOGEN IDEC MA INC.; CHAO, Jianhua; ENYEDY, Istvan, J.; GUERTIN, Kevin; HUTCHINGS, Richard, H.; JONES, John, Howard; POWELL, Noel; VANVLOTEN, Kurt, D.
Patent: WO2014/8214 A1, 2014 ;
Location in patent: Paragraph 00319-00320 ;
反应条件
sulfuric acid 8 h; Ambient temperature;
参考文献
Balasubramaniyan, V.; Argade, N. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 906 - 908
反应条件
1: 95 percent / benzene; diethyl ether; dioxane / Ambient temperature 2: 85 percent / H2SO4 / 8 h / Ambient temperature View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 27, # 1-12 p. 906 - 908
反应条件
sodium hydride in tetrahydrofuran; dimethylsulfoxide-d6 T=20°C; Dieckmann condensation;
参考文献
ONO PHARMACEUTICAL CO., LTD.
Patent: EP1475368 A1, 2004 ;
Location in patent: Page 42 ;
反应条件
1: NaH / dimethylsulfoxide-d6; tetrahydrofuran / 20 °C 2: H2O / dimethylsulfoxide / 150 °C View Scheme
参考文献
Kling, Andreas; Backfisch, Gisela; Delzer, Juergen; Geneste, Herve; Graef, Claudia; Hornberger, Wilfried; Lange, Udo E. W.; Lauterbach, Arnulf; Seitz, Werner; Subkowski, Thomas
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1319 - 1341
