4-氯联苯-2-胺盐酸盐合成路线 (共 20 条)
反应条件
iron (III) acetylacetonate; hydrazine hydrate in methanol T=150°C; Microwave irradiationGreen chemistry;
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 40 p. 10190 - 10193
反应条件
palladium diacetate; sodium carbonate in water; acetone T=35°C; 12 h;
参考文献
Organic Letters, , vol. 15, # 17 p. 4544 - 4547
反应条件
sodium hydroxide in water T=75°C;
参考文献
US2013/338369 A1, ;
Paragraph 0243; 0244; 0343; 0344; 0345; 0346; 0347-0349 ;
反应条件
1: bis(4-chlorophenyl)borinic acid With sodium hydroxide in tetrahydrofuran; water T=20°C; 1 h; 2: With triphenylphosphine in tetrahydrofuran; water T=20°C; 0.5 h; 3: 1-Bromo-2-aminobenzene With hydrogenchloride; palladium dichloride in tetrahydrofuran; water T=100°C; P=2625.26 Torr; 12 h;
参考文献
WO2006/92429 A1, ;
Page/Page column 11-12 ;
反应条件
1: para-dichlorobenzene With magnesium; ethylene dibromide; lithium chloride in tetrahydrofuran T=25°C; Negishi coupling reaction; 0.5 h; 2: With zinc(II) chloride in tetrahydrofuran T=25°C; Negishi coupling reaction; 0.5 h; 3: 1-Bromo-2-aminobenzene With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate in tetrahydrofuran T=25°C; Negishi coupling reaction; 3 h;
参考文献
Synlett, , # 14 art. no. S03411ST, p. 2064 - 2068
反应条件
10 palladium on activated carbon; hydrogen in methanol T=40°C; P=37503.8 Torr;
参考文献
Advanced Synthesis and Catalysis, , vol. 352, # 17 p. 3089 - 3097
反应条件
1: With dihydrogen peroxide; sodium hydroxide in ethanol; water 2: With sodium hypochlorite; sodium hydroxide in ethanol; water Hofmann rearrangement;
参考文献
Advanced Synthesis and Catalysis, , vol. 353, # 9 p. 1543 - 1550
反应条件
sodium methylate in 1,4-dioxane T=100°C; Suzuki-Miyaura Coupling; 25 h; Schlenk technique;
参考文献
ACS Catalysis, , vol. 3, # 12 p. 2776 - 2789
反应条件
oxygen; sodium hydroxide in water T=60°C; 33 h; regioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 79, # 5 p. 2314 - 2320
反应条件
manganese(IV) oxide in acetonitrile T=20°C; Overall yield = 54 percent; regioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 77, # 23 p. 10699 - 10706