2-氯-联苯-4-胺盐酸盐合成路线 (共 9 条)
反应条件
palladium diacetate; potassium carbonate; triphenylphosphine in toluene Suzuki coupling; 24 h; Inert atmosphereReflux;
参考文献
Davies, Matthew; Heikkilae, Timo; McConkey, Glenn A.; Fishwick, Colin W. G.; Parsons, Mark R.; Johnson, A. Peter
Journal of Medicinal Chemistry, 2009 , vol. 52, # 9 p. 2683 - 2693
反应条件
manganese(IV) oxide in acetonitrile T=20°C; Overall yield = 70 percent; regioselective reaction;
参考文献
Jasch, Hannelore; Scheumann, Julia; Heinrich, Markus R.
Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10699 - 10706
反应条件
water; iron; benzene
参考文献
Byron,D.J. et al.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 840 - 845
反应条件
1: hydrogenchloride; sodium nitrite / water; acetic acid / 1 h / 0 °C 2: manganese(IV) oxide / acetonitrile / 20 °C View Scheme
参考文献
Jasch, Hannelore; Scheumann, Julia; Heinrich, Markus R.
Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10699 - 10706
反应条件
PPA; trifluoroacetic acid T=50°C; Substitution; decomposition; trifluoroacetylation; 3 h; Further byproducts.;
参考文献
Takeuchi, Hiroshi; Taniguchi, Tomohito; Ueda, Takahiro
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 2 p. 295 - 300
反应条件
PPA; trifluoroacetic acid T=20°C; Substitution; decomposition; trifluoroacetylation; 3 h; Further byproducts. Title compound not separated from byproducts.;
参考文献
Takeuchi, Hiroshi; Taniguchi, Tomohito; Ueda, Takahiro
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 2 p. 295 - 300
反应条件
PPA; trifluoroacetic acid T=20°C; Substitution; decomposition; trifluoroacetylation; 3 h; Further byproducts. Title compound not separated from byproducts.;
参考文献
Takeuchi, Hiroshi; Taniguchi, Tomohito; Ueda, Takahiro
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 2 p. 295 - 300
反应条件
1: (i) (diazotization), (ii) /BRN= 4520686/, aq. NaHCO3 2: aq. NaOH / ethanol View Scheme
参考文献
Byron,D.J. et al.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 840 - 845
反应条件
Cu2Cl2; HNO2 Sandmeyer reaction;
参考文献
Bolgar; et al.
Chemosphere, 1995 , vol. 31, # 2 p. 2687 - 2705