2’-甲基-[1,1’-联苯]-4-胺合成路线 （共 15 条）
反应条件
potassium fluoride; tris(dibenzylideneacetone)dipalladium (0); tri-tert-butyl phosphine in tetrahydrofuran T=20°C; Suzuki cross-coupling; 4 h;
参考文献
Littke, Adam F.; Dai, Chaoyang; Fu, Gregory C.
Journal of the American Chemical Society, 2000 , vol. 122, # 17 p. 4020 - 4028
反应条件
potassium fluoride; 18-crown-6 ether; bis-phenanthrylimidazolium chloride; palladium diacetate in tetrahydrofuran T=50°C; Suzuki-Miyaura coupling; 24 h;
参考文献
Song, Chun; Ma, Yudao; Chai, Qiang; Ma, Chanqin; Jiang, Wei; Andrus, Merritt B.
Tetrahedron, 2005 , vol. 61, # 31 p. 7438 - 7446
反应条件
K3PO4*7H2O; palladium diacetate in water; N,N-dimethyl-formamide T=80°C; Suzuki Coupling; 0.833333 h;
参考文献
Chahdoura, Faouzi; Pradel, Christian; Gomez, Montserrat
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3648 - 3660
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
Hecht; El-Bayoumy; Tulley; LaVoie
Journal of Medicinal Chemistry, 1979 , vol. 22, # 8 p. 981 - 987
反应条件
[(P{(NC5H10)(C6H11)2})2Pd(Cl)2] in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=100°C; Negishi cross-coupling reaction; 1 h; In air;
参考文献
Bolliger, Jeanne L.; Frech, Christian M.
Chemistry - A European Journal, 2010 , vol. 16, # 36 p. 11072 - 11081
反应条件
2: H2 / Pd-C / ethanol View Scheme
参考文献
Hecht; El-Bayoumy; Tulley; LaVoie
Journal of Medicinal Chemistry, 1979 , vol. 22, # 8 p. 981 - 987
反应条件
2: H2 / Pd-C / ethanol View Scheme
参考文献
Hecht; El-Bayoumy; Tulley; LaVoie
Journal of Medicinal Chemistry, 1979 , vol. 22, # 8 p. 981 - 987
反应条件
trifluorormethanesulfonic acid T=5°C; 0.5 h; Further byproducts given;
参考文献
Shudo, Koichi; Ohta, Toshiharu; Okamoto, Toshihiko
Journal of the American Chemical Society, 1981 , vol. 103, # 3 p. 645 - 653
反应条件
trifluorormethanesulfonic acid T=5°C; 0.5 h; Further byproducts given;
参考文献
Shudo, Koichi; Ohta, Toshiharu; Okamoto, Toshihiko
Journal of the American Chemical Society, 1981 , vol. 103, # 3 p. 645 - 653
反应条件
1: (i) (diazotization), (ii) /BRN= 1072099/, aq. NaOH, (iii) aq. KOH, MeOH 2: (i) SOCl2, (ii) aq. NH3 3: aq. NaOBr View Scheme
参考文献
Byron,D.J. et al.
Journal of the Chemical Society, 1963 , p. 2246 - 2256
