反-4-(氨甲基)环己烷甲酸合成路线 （共 25 条）
反应条件
nickel monoaluminide in methanol; water; acetone
参考文献
Mitsubishi Chemical Industries Ltd.
Patent: US3950405 A1, 1976 ;
反应条件
triethylamine in hydrous methanol
反应条件
hydrogenchloride in water 1 h; Kinetics;
参考文献
Journal of Computer-Aided Molecular Design, , vol. 27, # 7 p. 615 - 635
反应条件
1: aq. NaOH 2: SOCl2 3: Et3N 4: H2, AcOH / Pd-C View Scheme
参考文献
Okano; Inaoka; Funabashi; Iwamoto; Isoda
Journal of medicinal chemistry, 1972 , vol. 15, # 3 p. 247 - 255
反应条件
sulfuric acid in ethanol 17 h; Heating / reflux;
参考文献
Dublanchet, Anne-Claude; Compere, Delphine; Cluzeau, Philippe; Blais, Stephane; Denis, Alexis; Ducrot, Pierre; Courte, Karine; Descamps, Sophie
Patent: US2004/72871 A1, 2004 ;
Location in patent: Page/Page column 18 ;
反应条件
hydrogenchloride in water 2 h; Reflux;
参考文献
Shonberg, Jeremy; Herenbrink, Carmen Klein; Lopez, Laura; Christopoulos, Arthur; Scammells, Peter J.; Capuano, Ben; Lane, J. Robert
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9199 - 9221
反应条件
thionyl chloride T=0 - 70°C; 1.16667 h;
参考文献
KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; Kim, Tae-Jeong; Chang, Yong Min; Kim, Hee-Kyung; Gu, Sung-Wook
Patent: US2013/231475 A1, 2013 ;
Location in patent: Paragraph 0043-0045 ;
反应条件
sodium hydrogencarbonate in 1,4-dioxane
参考文献
Brennauer, Albert; Keller, Max; Freund, Matthias; Bernhardt, Guenther; Buschauer, Armin
Tetrahedron Letters, 2007 , vol. 48, # 39 p. 6996 - 6999
反应条件
hydrogenchloride; sodium hydroxide in 1,4-dioxane; chloroform; water
参考文献
Kureha Chemical Industry Co., Ltd.
Patent: EP1273571 A1, 2003 ;
反应条件
sodium chloride; triethylamine in water (300 ml)-THF
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6235731 B1, 2001 ;
