反应条件
1: bromine / acetic acid / 19.5 h / 20 °C
2: trichlorophosphate / N,N-dimethyl-formamide / 3 h / Reflux
3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 20 - 130 °C / Microwave irradiation
View Scheme
参考文献
Nishimura, Nobuko; Siegmund, Aaron; Liu, Longbin; Yang, Kevin; Bryan, Marian C.; Andrews, Kristin L.; Bo, Yunxin; Booker, Shon K.; Caenepeel, Sean; Freeman, Daniel; Liao, Hongyu; McCarter, John; Mullady, Erin L.; San Miguel, Tisha; Subramanian, Raju; Tamayo, Nuria; Wang, Ling; Whittington, Douglas A.; Zalameda, Leeanne; Zhang, Nancy; Hughes, Paul E.; Norman, Mark H.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4735 - 4751