1: 2.) Me2NH*BH3 / 1.) glacial acetic acid, r.t., 15 min, 2.) glacial acetic acid, r.t., 20 min; 60 deg C, 10 min 2: 75 percent / trifluoroacetic acid / 1.5 h / Heating 3: NEt3 / dimethylformamide / 0.25 h / 5 °C 4: dimethylformamide / 72 h / Ambient temperature 5: 10 percent / NaOH, H2O / 1.5 h / Heating View Scheme

1: 78 percent / CH2Cl2 / 1 h / Ambient temperature 2: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 2 h, 2.) ether, hexane, -78 deg C to r.t. 3: 62 percent / NaOH, H2O / 4 h / Ambient temperature 4: 2.) Me2NH*BH3 / 1.) glacial acetic acid, r.t., 15 min, 2.) glacial acetic acid, r.t., 20 min; 60 deg C, 10 min 5: 75 percent / trifluoroacetic acid / 1.5 h / Heating 6: NEt3 / dimethylformamide / 0.25 h / 5 °C 7: dimethylformamide / 72 h / Ambient temperature 8: 10 percent / NaOH, H2O / 1.5 h / Heating View Scheme

1: 75 percent / trifluoroacetic acid / 1.5 h / Heating 2: NEt3 / dimethylformamide / 0.25 h / 5 °C 3: dimethylformamide / 72 h / Ambient temperature 4: 10 percent / NaOH, H2O / 1.5 h / Heating View Scheme

1: NEt3 / dimethylformamide / 0.25 h / 5 °C 2: dimethylformamide / 72 h / Ambient temperature 3: 10 percent / NaOH, H2O / 1.5 h / Heating View Scheme

1: dimethylformamide / 72 h / Ambient temperature 2: 10 percent / NaOH, H2O / 1.5 h / Heating View Scheme

potassium hydroxide; sodium hydroxide 1.) Acetic acid, 1 h, reflux; 2.) H2O (pH 8.8), 18 h, room temp.; 3.) 20 h, reflux; Yield given. Multistep reaction;

ethanol Loesung vom pH 4;

1: T=20°C; 96 h; 2: With trifluoroacetic acid in water 48.3333 h;

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