3-环丙基-3-氧代丙腈合成路线 （共 14 条）
反应条件
sodium hydride in tetrahydrofuran T=70°C; 16 h;
参考文献
Getlik, Matthaeus; Gruetter, Christian; Simard, Jeffrey R.; Nguyen, Hoang D.; Robubi, Armin; Aust, Beate; Van Otterlo, Willem A.L.; Rauh, Daniel
European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 1 - 15
反应条件
sodium hydride in tetrahydrofuran 15 h; Heating / reflux;
参考文献
WO2007/27842 A1, ;
Page/Page column 69 ;
反应条件
n-butyllithium in tetrahydrofuran; water; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US5260285 A1, 1993 ;
US 5260285 A
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2 h; 2: in tetrahydrofuran; hexane T=-78°C; 1 h; 3: With hydrogenchloride in tetrahydrofuran; hexane; water pH=3;
参考文献
WO2007/149907 A2, ;
Page/Page column 44 ;
反应条件
lithium diisopropyl amide in tetrahydrofuran; acetonitrile T=20°C; 1 h; Inert atmosphere;
参考文献
US2013/116246 A1, ;
Paragraph 0375 ;
反应条件
1: anhydrous cyanoacetic acid With isopropylmagnesium chloride in tetrahydrofuran; dichloromethane 2: cyclopropanecarboxylic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran; dichloromethane T=20°C; 60 h; 3: With hydrogenchloride; water in tetrahydrofuran; dichloromethane T=0°C; 1 h;
参考文献
WO2005/90313 A1, ;
Page/Page column 136-137 ;
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; hexane
反应条件
tetrabutylammomium bromide in acetonitrile T=20°C; Electrochemical reaction;
参考文献
Petrosyan; Neverov; Sigacheva
Russian Chemical Bulletin, 2007 , vol. 56, # 11 p. 2184 - 2188
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; hexane
反应条件
1: With hydroxylammonium sulphate; sodium hydroxide in water T=45°C; pH=7 - 8; 72 h; Inert atmosphere; 2: With hydrogenchloride in water T=50°C; 2.5 h; Inert atmosphere;
参考文献
Johnson, Leland; Powers, James; Ma, Fupeng; Jendza, Keith; Wang, Bing; Meredith, Erik; Mainolfi, Nello
Synthesis (Germany), 2013 , vol. 45, # 2 p. 171 - 173
