2-氯-4-(二乙氧基甲基)吡啶合成路线 （共 5 条）
反应条件
1: 8.42 g / PTSA / toluene / 48 h / Heating 2: m-CPBA / CH2Cl2 / 4 deg C, 30 min then r.t., 2 h 3: 1.) POCl3; 2.) PTSA / 1.) reflux, 6 h; 2.) EtOH, toluene, reflux, 6 h View Scheme
参考文献
Watson, Samuel E.; Markovich, Anatoly
Heterocycles, 1998 , vol. 48, # 10 p. 2149 - 2155
反应条件
1: m-CPBA / CH2Cl2 / 4 deg C, 30 min then r.t., 2 h 2: 1.) POCl3; 2.) PTSA / 1.) reflux, 6 h; 2.) EtOH, toluene, reflux, 6 h View Scheme
参考文献
Watson, Samuel E.; Markovich, Anatoly
Heterocycles, 1998 , vol. 48, # 10 p. 2149 - 2155
反应条件
toluene-4-sulfonic acid; trichlorophosphate 1.) reflux, 6 h; 2.) EtOH, toluene, reflux, 6 h; Yield givenMultistep reaction;
参考文献
Watson, Samuel E.; Markovich, Anatoly
Heterocycles, 1998 , vol. 48, # 10 p. 2149 - 2155
反应条件
lithium aluminium tetrahydride; toluene-4-sulfonic acid 1.) THF, -78 deg C, 2 h; 2.) toluene, reflux, 36 h; Yield givenMultistep reaction. Yields of byproduct given;
参考文献
Watson, Samuel E.; Markovich, Anatoly
Heterocycles, 1998 , vol. 48, # 10 p. 2149 - 2155
反应条件
in tetrahydrofuran
16 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/9602 A1, 2004 ;
Location in patent: Page 66 ;
WO 2004/009602 A1
