3,4,5-三甲氧基苯甲酸合成路线 （共 210 条）
反应条件
1: water containing CHCl3; bromine
2: aqueous NaOH; copper-powder
View Scheme
参考文献
Interlab Corporation
Patent: US5977077 A1, 1999 ;
参考文献
Cabre-Castellvi, Juan; Palomo-Coll, Antonio Luis
Tetrahedron Letters, 1980 , vol. 21, p. 4179 - 4182
反应条件
silica gel in anhydrous xylene
Reflux;
参考文献
Yang, Xiao-Dong; Zeng, Xiang-Hui; Zhao, Yuan-Hong; Wang, Xue-Quan; Pan, Zhi-Qiang; Li, Liang; Zhang, Hong-Bin
Journal of Combinatorial Chemistry, 2010 , vol. 12, # 3 p. 307 - 310
参考文献
King; King
Journal of the Chemical Society, 1942 , p. 726
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Barltrop; Nicholson
Journal of the Chemical Society, 1948 , p. 116,120
反应条件
1: water containing CHCl3; bromine
2: aqueous NaOH; copper-powder
3: AlBr3; benzene
View Scheme
参考文献
Mayer; Fikentscher
Chemische Berichte, 1956 , vol. 89, p. 511,517
反应条件
trichlorophosphate
5 h; Heating;
参考文献
Rose
Journal of Heterocyclic Chemistry, 1992 , vol. 28, # 8 p. 2005 - 2012
反应条件
ammonia; lithium in tetrahydrofuran; tert-butyl alcohol
参考文献
Tobin, Paul S.; Basu, Swapan K.; Grosserode, Robert S.; Wheeler, Desmond M.S.
Journal of Organic Chemistry, 1980 , vol. 45, # 7 p. 1250 - 1253
反应条件
ammonia; sodium in ethanol
1.) -78 deg C, 45 min, 2.) reflux, 20 min; Yield given. Yields of byproduct given;
参考文献
Smith III; Richmond
Journal of the American Chemical Society, 1983 , vol. 105, # 3 p. 575 - 585
反应条件
ammonia; sodium in ethanol
1.) -78 deg C, 45 min, 2.) reflux, 20 min; Yield given. Yields of byproduct given;
参考文献
Smith III; Richmond
Journal of the American Chemical Society, 1983 , vol. 105, # 3 p. 575 - 585
反应条件
ammonia; sodium; toluene-4-sulfonic acid
1.) ethanol, -78 deg C, 45 min, 2.) ethanol-benzene, reflux, 48 h; Yield given. Multistep reaction;
参考文献
Smith III; Richmond
Journal of the American Chemical Society, 1983 , vol. 105, # 3 p. 575 - 585
