4-苯胺-1-苯甲基哌啶合成路线 （共 15 条）
反应条件
sodium tris(acetoxy)borohydride; acetic acid in 1,2-dichloro-ethane T=20°C; 3 h;
参考文献
WO2005/60947 A2, ;
Page/Page column 33 ;
WO 2005/060947 A2
反应条件
1: With sodium tetrahydroborate in methanol 1 h; Heating; 2: With sodium hydroxide in methanol Further stages.;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 8 p. 2161 - 2165
反应条件
1.1: 73 percent / AcOH / toluene / 2 h / Heating 2.1: NaBH4 / methanol / 1 h / Heating 2.2: 81 percent / NaOH / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 8 p. 2161 - 2165
反应条件
1.1: Na / toluene / 2 h / Heating 1.2: 41 percent / HCl / toluene / Heating 2.1: 73 percent / AcOH / toluene / 2 h / Heating 3.1: NaBH4 / methanol / 1 h / Heating 3.2: 81 percent / NaOH / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 8 p. 2161 - 2165
反应条件
1.1: 95 percent / methanol / 4 h / Heating 2.1: Na / toluene / 2 h / Heating 2.2: 41 percent / HCl / toluene / Heating 3.1: 73 percent / AcOH / toluene / 2 h / Heating 4.1: NaBH4 / methanol / 1 h / Heating 4.2: 81 percent / NaOH / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 8 p. 2161 - 2165
反应条件
1: TiCl4 / CH2Cl2 / 5 °C 2: NaBH4 / methanol; CH2Cl2 / 0 - 5 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2535 - 2539
反应条件
1: 1,2-dichloro-ethane / 20 °C 2: sodium hydroxide / water 3: hydrogen; palladium 10 on activated carbon / methanol; acetic acid / 50 °C 4: potassium carbonate; tetrabutylammomium bromide / acetonitrile View Scheme
参考文献
Gupta, Pradeep Kumar; Yadav, Shiv Kumar; Bhutia, Yangchen Doma; Singh, Poonam; Rao, Pooja; Gujar, Niranjan Laxman; Ganesan, Kumaran; Bhattacharya, Rahul
Medicinal Chemistry Research, 2013 , vol. 22, # 8 p. 3888 - 3896
反应条件
1: toluene / 3 h / Heating 2: 95 percent / H2, conc. HCl / 10 percent Pd/C / ethanol / 50 °C / 2068.6 Torr 3: 7 h / 100 °C View Scheme
参考文献
Brine; Boldt; Huang; Sawyer; Carroll
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 3 p. 677 - 686
反应条件
1: 54 percent / TEA / benzene / 24 h 2: 61 percent / H2 / Pd/C / ethanol / 60 h / 20 °C View Scheme
参考文献
Gupta, Pradeep Kumar; Yadav, Shiv Kumar; Bhutia, Yangchen Doma; Singh, Poonam; Rao, Pooja; Gujar, Niranjan Laxman; Ganesan, Kumaran; Bhattacharya, Rahul
Medicinal Chemistry Research, 2013 , vol. 22, # 8 p. 3888 - 3896
反应条件
TEA in benzene 24 h;
参考文献
Lee, Yeon Sun; Nyberg, Joel; Moye, Sharif; Agnes, Richard S.; Davis, Peg; Ma, Shou-wu; Lai, Josephine; Porreca, Frank; Vardanyan, Ruben; Hruby, Victor J.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2161 - 2165
