4'-溴甲基联苯-2-甲酸叔丁酯合成路线 （共 19 条）
反应条件
azobisisobutyronitrile; sodium acetate in methyl acetate; water; isopropyl alcohol; acetone
参考文献
Schneider, Heinrich; Schneider, Margarete
Patent: US2002/95042 A1, 2002 ;
反应条件
1: 94 percent / sulfuric acid / diethyl ether / 25 °C 2: NBS, AIBN / CCl4 / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 15 p. 2172 - 2181
反应条件
1: 95 percent / tetrakis(triphenylphosphine)palladium, 2M aq. sodium carbonate / toluene; ethanol / 4 h / Heating 2: 82 percent / NBS, AIBN / CCl4 / 4.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 7 p. 897 - 906
反应条件
N-bromosuccinmide; triphenylphosphine in dichloromethane T=-78 - 20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 6 p. 1913 - 1917
反应条件
1: dicyclohexyl-carbodiimide / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 h / 20 °C / Inert atmosphere 2: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 0.67 h / 100 °C / Sealed vial 3: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 2 h / 100 °C View Scheme
反应条件
1: 95 percent / tetrakis(triphenylphosphine)palladium, 2M aq. sodium carbonate / toluene; ethanol / 4 h / Heating 2: 82 percent / NBS, AIBN / CCl4 / 4.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 7 p. 897 - 906
反应条件
1: 99 percent / NaOH / H2O; methanol / Heating 2: 94 percent / sulfuric acid / diethyl ether / 25 °C 3: NBS, AIBN / CCl4 / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 15 p. 2172 - 2181
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: 88 percent / 4.5 N aq. HCl / 12 h / Heating 3: oxalyl chloride / CH2Cl2 / 3 h / 25 °C 4: tetrahydrofuran / 1 h / 25 °C 5: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: tetrahydrofuran / 1 h / 25 °C 2: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: thionyl chloride / 1 h / 25 °C 2: tetrahydrofuran / 2 h / 20 °C 3: 88 percent / 4.5 N aq. HCl / 12 h / Heating 4: oxalyl chloride / CH2Cl2 / 3 h / 25 °C 5: tetrahydrofuran / 1 h / 25 °C 6: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
