4'-溴甲基-2-甲酸甲酯联苯合成路线 （共 24 条）
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane Reflux;
参考文献
Archiv der Pharmazie, , vol. 344, # 9 p. 617 - 626
反应条件
phosphorus tribromide; sodium hydrogencarbonate in pyridine; hexane
参考文献
US5554757 A1, ;
US 5554757 A
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
US5554757 A1, ;
US 5554757 A
反应条件
dibenzoyl peroxide in tetrachloromethane
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin; 2,2'-azo-bisisobutyronitrile in chloroform T=60 - 65°C;
参考文献
Organic Process Research and Development, , vol. 11, # 1 p. 81 - 85
反应条件
1: benzene; methanol; hexane 2: NBS; benzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 5 p. 703 - 714
反应条件
in tetrachloromethane
反应条件
1: PdCl2; aq. NaOH 2: benzene; methanol; hexane 3: NBS; benzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 5 p. 703 - 714
反应条件
1: PdCl2; aq. NaOH 2: benzene; methanol; hexane 3: NBS; benzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 5 p. 703 - 714
反应条件
1: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h 2: NBS, AIBN / CCl4 / 3 h / Heating View Scheme
参考文献
Farmaco, , vol. 52, # 3 p. 147 - 155
