4-(8-甲基-8,9-二氢-7h-[1,3]二氧代lo[4,5:4,5]苯并[1,2-d][1,2]二氮杂革-5-基)苯胺合成路线 （共 6 条）
反应条件
pyridine; hydrogenchloride; sodium hydroxide; sodium borohydride in water
参考文献
Biogal Gyogyszergyar
Patent: US4835152 A1, 1989 ;
反应条件
1.1: Hg(OAc)2 / tetrahydrofuran / 1 h / 20 °C 1.2: 96 percent / NaBH4; aq. NaOH / tetrahydrofuran / 1 h 2.1: 75 percent / pyridinium chlorochromate / CH2Cl2 / 20 °C 3.1: 60 percent / P2O5 / 1,2-dichloro-ethane / 8 h / 20 °C 4.1: 50 percent / hydrazine hydrate / ethanol / 2 h / 20 °C 5.1: 80 percent / SnCl2 / ethanol / 1 h / 70 °C 6.1: 83 percent / NaBH3CN; HCl / methanol / 1 h / 20 °C View Scheme
参考文献
Zappala, Maria; Grasso, Silvana; Micale, Nicola; Polimeni, Santina; De Micheli, Carlo
Synthetic Communications, 2002 , vol. 32, # 4 p. 527 - 533
反应条件
1: 75 percent / pyridinium chlorochromate / CH2Cl2 / 20 °C 2: 60 percent / P2O5 / 1,2-dichloro-ethane / 8 h / 20 °C 3: 50 percent / hydrazine hydrate / ethanol / 2 h / 20 °C 4: 80 percent / SnCl2 / ethanol / 1 h / 70 °C 5: 83 percent / NaBH3CN; HCl / methanol / 1 h / 20 °C View Scheme
参考文献
Zappala, Maria; Grasso, Silvana; Micale, Nicola; Polimeni, Santina; De Micheli, Carlo
Synthetic Communications, 2002 , vol. 32, # 4 p. 527 - 533
反应条件
1: 60 percent / P2O5 / 1,2-dichloro-ethane / 8 h / 20 °C 2: 50 percent / hydrazine hydrate / ethanol / 2 h / 20 °C 3: 80 percent / SnCl2 / ethanol / 1 h / 70 °C 4: 83 percent / NaBH3CN; HCl / methanol / 1 h / 20 °C View Scheme
参考文献
Zappala, Maria; Grasso, Silvana; Micale, Nicola; Polimeni, Santina; De Micheli, Carlo
Synthetic Communications, 2002 , vol. 32, # 4 p. 527 - 533
反应条件
acetic anhydride; triethylamine in chloroform
参考文献
Gyogyszerku-tato Intezet Kft
Patent: US5459137 A1, 1995 ;
Title/Abstract Full Text Show Details
Cyogyszerkutato Intezet KFT
Patent: US5639751 A1, 1997 ;
反应条件
acetic anhydride in chloroform
参考文献
Gyogyszerkutato Intezet Kv.
Patent: US5521174 A1, 1996 ;
