(4-氟苯氧基)(二甲基)(2-甲基-2-丙基)硅烷合成路线 （共 10 条）
反应条件
1H-imidazole in N,N-dimethyl-formamide T=25°C; 12 h;
参考文献
Kawase; Sinhababu; Borchardt
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 11 p. 2939 - 2946
反应条件
potassium fluoride in N,N-dimethyl-formamide T=25°C; 8 h;
参考文献
Sinhababu, Achintya K.; Kawase, Masami; Borchardt, Ronald T.
Tetrahedron Letters, 1987 , vol. 28, # 36 p. 4139 - 4142
反应条件
perchloric acid immobilized on silica gel in dichloromethane 10 h;
参考文献
Du, Ti-Jian; Wu, Qin-Pei; Liu, Hai-Xia; Chen, Xi; Shu, Yi-Nan; Xi, Xiao-Dong; Zhang, Qing-Shan; Li, Yun-Zheng
Tetrahedron, 2011 , vol. 67, # 6 p. 1096 - 1101
反应条件
potassium fluoride in N,N-dimethyl-formamide T=25°C; 5.5 h;
参考文献
Sinhababu, Achintya K.; Kawase, Masami; Borchardt, Ronald T.
Tetrahedron Letters, 1987 , vol. 28, # 36 p. 4139 - 4142
反应条件
potassium fluoride; hydrogen bromide in N,N-dimethyl-formamide T=25°C; 0.5 h;
参考文献
Sinhababu, Achintya K.; Kawase, Masami; Borchardt, Ronald T.
Synthesis, 1988 , # 9 p. 710 - 712
反应条件
1.1: sec-BuLi / tetrahydrofuran; hexane / 0.5 h / -65 °C 1.2: trimethyl borate / tetrahydrofuran; hexane / 1 h / -65 °C 1.3: 73 percent / aq. H2O2; acetic acid / 0.5 h / 0 °C 2.1: 99 percent / imidazole / dimethylformamide / 1 h / 0 °C 3.1: sec-BuLi / tetrahydrofuran; hexane / 1 h / -70 °C 3.2: 92 percent / tetrahydrofuran; hexane / 1.5 h / 20 °C 4.1: 55 percent / KF / dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Zbinden, Katrin Groebke; Banner, David W.; Hilpert, Kurt; Himber, Jacques; Lave, Thierry; Riederer, Markus A.; Stahl, Martin; Tschopp, Thomas B.; Obst-Sander, Ulrike
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 15 p. 5357 - 5369
反应条件
1: 1.) sec-BuLi, 2.) tetrabutylammonium fluoride / 1.) THF, hexane, -77 deg C, 0.5 h, 2.) THF, hexane, from -77 deg C to RT 2: 76 percent / K2CO3 / acetone / Ambient temperature View Scheme
参考文献
Kirk, Kenneth L.; Olubajo, Olarangbe; Buchhold, Konstantin; Lewandowski, Gail A.; Gusovsky, Fabian; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1982 - 1988
反应条件
tetrabutyl ammonium fluoride; sec.-butyllithium 1.) THF, hexane, -77 deg C, 0.5 h, 2.) THF, hexane, from -77 deg C to RT; Multistep reaction;
参考文献
Kirk, Kenneth L.; Olubajo, Olarangbe; Buchhold, Konstantin; Lewandowski, Gail A.; Gusovsky, Fabian; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1982 - 1988
反应条件
1: 1.) sec-BuLi / 1.) THF, from -78 to -70 deg C, 30 min, 2.) THF 2: (n-Bu)4NF View Scheme
参考文献
Furlano, David C.; Calderon, Silvia N.; Chen, George; Kirk, Kenneth L.
Journal of Organic Chemistry, 1988 , vol. 53, # 14 p. 3145 - 3147
反应条件
1.1: sec-BuLi / tetrahydrofuran; hexane / 0.5 h / -65 °C 1.2: trimethyl borate / tetrahydrofuran; hexane / 1 h / -65 °C 1.3: 73 percent / aq. H2O2; acetic acid / 0.5 h / 0 °C 2.1: 99 percent / imidazole / dimethylformamide / 1 h / 0 °C 3.1: sec-BuLi / tetrahydrofuran; hexane / 1 h / -70 °C 3.2: 92 percent / tetrahydrofuran; hexane / 1.5 h / 20 °C View Scheme
参考文献
Kawase; Sinhababu; Borchardt
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 11 p. 2939 - 2946
