4-溴-2,6-二叔丁基苯酚合成路线 （共 45 条）
反应条件
ammonium formate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; Heck Reaction; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Journal of Polymer Science, Part A: Polymer Chemistry, , vol. 50, # 22 p. 4647 - 4655
反应条件
sodium hydroxide; nickel monoaluminide; ethanol
参考文献
Hart; Cassis
Journal of the American Chemical Society, 1951 , vol. 73, p. 3179,3181
Full Text Show Details
Gulf Research and Devel. Co.
Patent: US2459597 , 1945 ;
反应条件
1: 4-bromo-2,6-di-tert-butylphenol With sodium hydride in tetrahydrofuran T=20°C; 1 h; 2: dimethyl sulfate in tetrahydrofuran 17 h; Heating;
参考文献
Journal of the American Chemical Society, , vol. 128, # 51 p. 16486 - 16487
反应条件
1: 4-bromo-2,6-di-tert-butylphenol With sodium hydride in dimethyl sulfoxide; oil T=0°C; Inert atmosphere; 2: methyl iodide in dimethyl sulfoxide; oil T=0 - 20°C; Inert atmosphere;
参考文献
Organic Letters, , vol. 10, # 23 p. 5429 - 5432
反应条件
1.1: BuLi / -78 °C 1.2: -50 °C 2.1: 40 percent / i-Bu2AlH; PdCl2(PPh3)2 / tetrahydrofuran; toluene / 48 h / Heating 3.1: 100 percent / TBAF View Scheme
参考文献
D'Amore, Franco; Lanata, Marta; Gallazzi, Maria C.; Zerbi, Giuseppe
Chemical Physics Letters, 2003 , vol. 377, # 1-2 p. 243 - 248
反应条件
1: 4-bromo-2,6-di-tert-butylphenol With sodium hydride in 1-methyl-pyrrolidin-2-one; mineral oil
T=20°C; 0.5 h; Inert atmosphereCooling with ice;
2: N,N-dimethylthiocarbamoyl chloride in 1-methyl-pyrrolidin-2-one; mineral oil
T=80°C; 4 h; Inert atmosphere;
参考文献
Novakova, Veronika; Miletin, Miroslav; Filandrova, Tereza; Lenco, Juraj; Ruiszicka, Ales; Zimcik, Petr
Journal of Organic Chemistry, 2014 , vol. 79, # 5 p. 2082 - 2093
反应条件
3-methoxy-phenol; copper; potassium carbonate in pyridine
T=180°C; 4 h;
参考文献
Coutts, Ian G. C.; Hamblin, Michael R.; Welsby, Sheila E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 493 - 497
反应条件
copper; potassium carbonate in pyridine
T=180°C; 4 h; other temperature(100 deg C), other solvent (NN-diethylacetamide, 150 deg C; N-methylpyrrolidone, 185 deg C), analogous reaction with 2-methoxyphenol; Product distribution;
参考文献
Coutts, Ian G. C.; Hamblin, Michael R.; Welsby, Sheila E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 493 - 497
反应条件
n-butyllithium in tetrahydrofuran
T=-78 - 20°C; Silylation;
参考文献
Bebbington, David; Monck, Nathaniel J. T.; Gaur, Suneel; Palmer, Alan M.; Benwell, Karen; Harvey, Victoria; Malcolm, Craig S.; Porter, Richard H. P.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2779 - 2782
反应条件
in tetrahydrofuran; hexane; water; benzene
参考文献
Polaroid Corporation
Patent: US4178447 A1, 1979 ;
