(5-溴-2-甲基苯基)(5-(4-氟苯基)-2-噻吩)甲酮合成路线 （共 4 条）
反应条件
AlCl3, aluminium chloride in dichloromethane T=0 - 20°C; Friedel Crafts acylation;
参考文献
Nomura, Sumihiro; Sakamaki, Shigeki; Hongu, Mitsuya; Kawanishi, Eiji; Koga, Yuichi; Sakamoto, Toshiaki; Yamamoto, Yasuo; Ueta, Kiichiro; Kimata, Hirotaka; Nakayama, Keiko; Tsuda-Tsukimoto, Minoru
Journal of Medicinal Chemistry, 2010 , vol. 53, # 17 p. 6355 - 6360
反应条件
1.1: potassium carbonate / tri-cyclo-hexyl-phosphine; tris-(dibenzylideneacetone)dipalladium(0) / ethanol; water / 90 °C / Inert atmosphere 2.1: AlCl3, aluminium chloride / dichloromethane / 0 - 20 °C 2.2: cooling with ice View Scheme
参考文献
TFCHEM; DELIENCOURT-GODEFROY, Geraldine; LOPES, Lenaig
Patent: WO2012/160218 A1, 2012 ;
WO 2012/160218 A1
反应条件
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 6 h / 20 °C 2.1: AlCl3, aluminium chloride / dichloromethane / 0 - 20 °C 2.2: cooling with ice View Scheme
参考文献
TFCHEM; DELIENCOURT-GODEFROY, Geraldine; LOPES, Lenaig
Patent: WO2012/160218 A1, 2012 ;
WO 2012/160218 A1
反应条件
triethylsilane; boron trifluoride diethyl etherate in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Nomura, Sumihiro; Sakamaki, Shigeki; Hongu, Mitsuya; Kawanishi, Eiji; Koga, Yuichi; Sakamoto, Toshiaki; Yamamoto, Yasuo; Ueta, Kiichiro; Kimata, Hirotaka; Nakayama, Keiko; Tsuda-Tsukimoto, Minoru
Journal of Medicinal Chemistry, 2010 , vol. 53, # 17 p. 6355 - 6360
