2,6-二氯-3-甲酰胺-5-氟吡啶合成路线 （共 14 条）
反应条件
1: With sulfuric acid T=60 - 65°C; 1 h; 2: With water T=20°C; Cooling;
参考文献
WO2011/147810 A1, ;
Page/Page column 24 ;
反应条件
ammonia in water T=-20 - 5°C; 0.5 h;
参考文献
EP2022793 A1, ;
Page/Page column 103 ;
EP2022793 A1, ;
Page/Page column 103 ;
EP 2022793 A1
反应条件
1: thionyl chloride / chloroform / 8 h / |Reflux 2: ammonium hydroxide / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 5 p. 1424 - 1427
反应条件
1: 77 percent / PCl5 / 2.5 h / 130 °C 2: 84 percent / conc. H2SO4 / 1 h / 60 - 65 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 35, # 6 p. 2280 - 2285
反应条件
1: zinc; acetic acid / methanol / 24 h / Reflux 2: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C View Scheme
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; Stasch, Johannes-Peter; Becker, Eva-Maria; Trübel, Hubert; Himmel, Herbert
Patent: US2013/158028 A1, 2013 ;
反应条件
boron trifluoride diethyl etherate in ethanol 1.) 60 deg C, 30 min; 2.) reflux, 16 h;
参考文献
Miyamoto; Egawa; Matsumoto
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 6 p. 2280 - 2285
反应条件
1: 81 percent / 35percent HCl / 3 h / 135 - 140 °C 2: 81 percent / SOCl2 / 1 h / Heating View Scheme
参考文献
Miyamoto; Matsumoto
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 12 p. 3211 - 3217
反应条件
1: 81 percent / 35percent HCl / 3 h / 135 - 140 °C 2: 81 percent / SOCl2 / 1 h / Heating 3: 1.) Mg, CCl4, EtOH / 1.) Et2O, reflux, 30 min, 2.) 10 min 4: p-toluenesulfonic acid / H2O / 2 h / Heating View Scheme
参考文献
Miyamoto; Matsumoto
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 12 p. 3211 - 3217
反应条件
hydrogenchloride T=135 - 140°C; 3 h;
参考文献
Miyamoto; Matsumoto
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 12 p. 3211 - 3217
