alpha-甲基-DL-苯丙氨酸合成路线 （共 31 条）
反应条件
1: With sodium hydroxide; tetraethylammonium bromide; (-)-(R,R)-TADDOL in toluene T=15 - 20°C; Substitution; 12 h; 2: With hydrogenchloride in water Hydrolysis; 0.25 h; Further stages.;
参考文献
Belokon, Yuri N.; Kochetkov, Konstantin A.; Churkina, Tatiana D.; Ikonnikov, Nikolai S.; Chesnokov, Alexey A.; Larionov, Oleg V.; Singh, Ishwar; Parmar, Virinder S.; Vyskocil, Stepan; Kagan, Henri B.
Journal of Organic Chemistry, 2000 , vol. 65, # 21 p. 7041 - 7048
反应条件
1: With cesium hydroxide; (-)-(R,R)-TADDOL in toluene T=15 - 20°C; Alkylation; benzylation; 12 h; 2: With hydrogenchloride in water; toluene Hydrolysis; Heating;
参考文献
Belokon'; Kochetkov; Churkina; Ikonnikov; Chesnokov; Larionov; Kagan
Russian Chemical Bulletin, 1999 , vol. 48, # 5 p. 917 - 923
反应条件
hydrogenchloride in tetrahydrofuran 2 h; Ambient temperature;
参考文献
Zanardi, Franca; Battistini, Lucia; Rassu, Gloria; Cornia, Mara; Casiraghi, Giovanni
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 19 p. 2471 - 2476
反应条件
water; ammonium chloride T=55 - 60°C; Behandeln der in Aether loeslichen Anteile des Reaktionsprodukts mit HCl;
参考文献
Journal of the American Chemical Society, , vol. 77, p. 700,702
反应条件
1: 96 percent / K2CO3, KOH / benzyl triethylammonium chloride / CH2Cl2 / 6 h / Ambient temperature 2: 1.) hydrochloric acid (1N); 2.) hydrochloric acid (6N) / 1.) ether, 12 h, room temp.; 2.) reflux, 4 h View Scheme
参考文献
Tetrahedron, , vol. 44, # 17 p. 5343 - 5354
反应条件
sodium hydroxide; Cu(salen) in toluene T=20°C; 48 h;
参考文献
Tetrahedron Letters, , vol. 44, # 10 p. 2045 - 2048
反应条件
tetrabutylammomium bromide; potassium carbonate in acetonitrile 48 h; Heatingfurther alkylation method; Product distribution;
参考文献
Journal of the American Chemical Society, , vol. 110, # 25 p. 8520 - 8525
反应条件
tetrabutylammomium bromide; potassium carbonate in acetonitrile 48 h; Heatingfurther alkylation method; Product distribution;
参考文献
Journal of the American Chemical Society, , vol. 110, # 25 p. 8520 - 8525
反应条件
hydrogenchloride; acetic acid T=95°C; 5.5 h; Heating; Yield given;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 30, # 6 p. 724 - 728
Khimiya Geterotsiklicheskikh Soedinenii, , # 6 p. 829 - 833
反应条件
1: 70 percent / CF3CO2Ag / CH2Cl2 / 2 h / 0 °C 2: 96 percent / 2,6-dimethylpyridine / CH2Cl2 / 1 h / Ambient temperature 3: 66 percent / CF3CO2H / CH2Cl2 / 2 h / 0 °C 4: KMnO4, dicyclohexano-18-crown-6 ether / CH2Cl2 / 2 h / Ambient temperature 6: 89 percent / aq. HCl / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 19 p. 2471 - 2476
