2-(羟基亚氨基)-N-(2-甲基苯基)乙酰胺合成路线 （共 10 条）
反应条件
hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate in water Heating;
参考文献
Boa, Andrew N.; Canavan, Shane P.; Hirst, Paul R.; Ramsey, Christopher; Stead, Andrew M.W.; McConkey, Glenn A.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1945 - 1967
反应条件
hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate in ethanol; water T=80°C; 3 h;
参考文献
Krapcho, A. Paul; Cadamuro, Sergio A.
Organic Preparations and Procedures International, 2004 , vol. 36, # 1 p. 74 - 76
反应条件
hydrogenchloride; hydroxylammonium sulphate
参考文献
Journal of Organic Chemistry, , vol. 41, # 21 p. 3356 - 3359
反应条件
1: 86percent H2SO4 / 1) 55 deg C, 10 min, 2) 75 deg C, 30 min 2: H2O2, NaOH View Scheme
参考文献
Zhao, Yu; Xiong, Li-Xia; Xu, Li-Ping; Wang, Hongxue; Xu, Han; Li, Hua-Bin; Tong, Jun; Li, Zheng-Ming
Research on Chemical Intermediates, 2013 , vol. 39, # 7 p. 3071 - 3088
反应条件
1: sulfuric acid / 0.33 h / 80 °C 2: dihydrogen peroxide; sodium hydroxide / water / 0 - 50 °C 3: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C View Scheme
参考文献
Zhao, Yu; Xiong, Li-Xia; Xu, Li-Ping; Wang, Hongxue; Xu, Han; Li, Hua-Bin; Tong, Jun; Li, Zheng-Ming
Research on Chemical Intermediates, 2013 , vol. 39, # 7 p. 3071 - 3088
反应条件
1.1: sulfuric acid / 0.33 h / 80 °C 2.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 50 °C 3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C 4.1: thionyl chloride / 3 h / |Reflux 4.2: 20 °C / |Cooling with ice View Scheme
参考文献
Zhao, Yu; Xiong, Li-Xia; Xu, Li-Ping; Wang, Hongxue; Xu, Han; Li, Hua-Bin; Tong, Jun; Li, Zheng-Ming
Research on Chemical Intermediates, 2013 , vol. 39, # 7 p. 3071 - 3088
反应条件
sulfuric acid T=70 - 75°C; Sandmeyer isatin synthesis; 0.166667 h;
参考文献
Boa, Andrew N.; Canavan, Shane P.; Hirst, Paul R.; Ramsey, Christopher; Stead, Andrew M.W.; McConkey, Glenn A.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1945 - 1967
反应条件
hydrogenchloride; hydroxylamine hydrochloride in water
参考文献
Doctor Andreu S.A.
Patent: US4053483 A1, 1977 ;
参考文献
Sandmeyer
Helvetica Chimica Acta, 1919 , vol. 2, p. 239
反应条件
1: sulfuric acid / 0.33 h / 80 °C
2: dihydrogen peroxide; sodium hydroxide / water / 0 - 50 °C
3: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C
4: thionyl chloride / 3 h / |Reflux
5: tetrahydrofuran / 20 °C / |Cooling with ice
View Scheme
参考文献
Zhao, Yu; Li, Yongqiang; Xiong, Lixia; Wang, Hongxue; Li, Zhengming
Chinese Journal of Chemistry, 2012 , vol. 30, # 8 p. 1748 - 1758
