1-溴-2,4,6-三甲氧基苯合成路线 （共 19 条）
反应条件
1: 1-bromo-2,4,6-trimethoxybenzene With n-butyllithium in tetrahydrofuran T=-78°C; Inert atmosphere; 2: With zinc(II) chloride in tetrahydrofuran T=-78 - 0°C; 0.75 h; Inert atmosphere; 3: benzyl bromide With PdCl2(DPEphos) in tetrahydrofuran T=0 - 70°C; Negishi coupling; Inert atmosphere;
参考文献
Dennis, Eric G.; Jeffery, David W.; Perkins, Michael V.; Smith, Paul A.
Tetrahedron, 2011 , vol. 67, # 11 p. 2125 - 2131
反应条件
1: 1-bromo-2,4,6-trimethoxybenzene With n-butyllithium in tetrahydrofuran T=-78°C; Inert atmosphere; 2: With zinc(II) chloride in tetrahydrofuran T=-78 - 0°C; 0.75 h; Inert atmosphere; 3: benzyl bromide With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=0 - 70°C; Inert atmosphere;
参考文献
Dennis, Eric G.; Jeffery, David W.; Perkins, Michael V.; Smith, Paul A.
Tetrahedron, 2011 , vol. 67, # 11 p. 2125 - 2131
反应条件
1: 1-bromo-2,4,6-trimethoxybenzene With n-butyllithium in tetrahydrofuran T=-78°C; Inert atmosphere; 2: With zinc(II) chloride in tetrahydrofuran T=-78 - 0°C; 0.75 h; Inert atmosphere; 3: benzyl chloride With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=0 - 70°C; Inert atmosphere;
参考文献
Dennis, Eric G.; Jeffery, David W.; Perkins, Michael V.; Smith, Paul A.
Tetrahedron, 2011 , vol. 67, # 11 p. 2125 - 2131
反应条件
potassium acetate; palladium diacetate in toluene T=100°C; 16 h; Inert atmosphere;
参考文献
Kawamorita, Soichiro; Ohmiya, Hirohisa; Iwai, Tomohiro; Sawamura, Masaya
Angewandte Chemie - International Edition, 2011 , vol. 50, # 36 p. 8363 - 8366
反应条件
1: With magnesium in tetrahydrofuran T=20°C; 2: With ammonia; iodine in tetrahydrofuran; water T=20°C;
参考文献
Ishii, Genki; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron Letters, 2011 , vol. 52, # 18 p. 2404 - 2406
反应条件
1: With magnesium in tetrahydrofuran T=20°C; 2 h; 2: With N,N-dimethyl-formamide in tetrahydrofuran T=0°C; 2 h; 3: With ammonia; iodine in tetrahydrofuran; water T=20°C; 2 h;
参考文献
Ishii, Genki; Harigae, Ryo; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2013 , vol. 69, # 5 p. 1462 - 1469
反应条件
1: Cu2O, collidine
2: (i) BBr3, CH2Cl2, (ii) /BRN= 385737/, Py
View Scheme
参考文献
Sattler; Glombitza
Archiv der Pharmazie, 1975 , vol. 308, # 11 p. 813 - 818
反应条件
copper(I) oxide; 2,3,5-trimethyl-pyridine
参考文献
Sattler; Glombitza
Archiv der Pharmazie, 1975 , vol. 308, # 11 p. 813 - 818
反应条件
1: Cu2O, collidine
2: (i) BBr3, CH2Cl2, (ii) /BRN= 385737/, Py
3: HCl / methanol
View Scheme
参考文献
Sattler; Glombitza
Archiv der Pharmazie, 1975 , vol. 308, # 11 p. 813 - 818
