(2E,4R)-4-[(1R,3AS,4E,7AR)-4-[(2E)-2-[(3S,5R)-3,5-双[[(叔丁基)二甲基硅]氧基]-2-亚甲基环己亚基]乙烯基]八氢-7A-甲基-1H-茚-1-基]-1-环丙基-2-戊烯-1-酮合成路线 （共 16 条）
反应条件
sodium hydroxide; tetrabutylammomium bromide; water in toluene T=15 - 30°C; Product distribution / selectivity;
参考文献
WO2005/95336 A2, ;
Page/Page column 38-39 ;
反应条件
1: (2-cyclopropyl-2-oxo-ethyl)-phosphonic acid dimethyl ester With sodium hexamethyldisilazane in tetrahydrofuran T=-50°C; 4.16667 h; 2: (5E,7E)-(1S,3R,20S)-1,3-bislt;lt;(1,1-dimethylethyl)dimethylsilylgt;oxygt;-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al in tetrahydrofuran T=-50 - 20°C; Product distribution / selectivity;
参考文献
WO2005/95336 A2, ;
Page/Page column 40 ;
反应条件
1: 87 percent / bromine / methanol / 0.5 h / Ambient temperature 2: 84 percent 3: 86 percent / 2N sodium hydroxide / H2O; CH2Cl2 5: N-methylmorpholine N-oxide, selenium dioxide 6: imidazole / dimethylformamide View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C 2: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C 3: NaHCO3 / aq. ethanol / Heating 5: N-methylmorpholine N-oxide, selenium dioxide 6: imidazole / dimethylformamide View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C 2: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C 3: NaHCO3 / aq. ethanol / Heating 5: N-methylmorpholine N-oxide, selenium dioxide 6: imidazole / dimethylformamide View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: liq. SO2 / 0.5 h / Heating 2: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C 3: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C 4: NaHCO3 / aq. ethanol / Heating 6: N-methylmorpholine N-oxide, selenium dioxide 7: imidazole / dimethylformamide View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
2: N-methylmorpholine N-oxide, selenium dioxide 3: imidazole / dimethylformamide View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: N-methylmorpholine N-oxide, selenium dioxide 2: imidazole / dimethylformamide View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: NaHCO3 / aq. ethanol / Heating 3: N-methylmorpholine N-oxide, selenium dioxide 4: imidazole / dimethylformamide View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: NaHCO3 / aq. ethanol / Heating 3: N-methylmorpholine N-oxide, selenium dioxide 4: imidazole / dimethylformamide View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
