8-羟基喹啉-N-氧化物合成路线 （共 25 条）
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
参考文献
Deyrup; Nowicki; Richards; Otero; Harrison; Baker
Naunyn-Schmiedeberg's Archives of Pharmacology, 1999 , vol. 359, # 3 p. 168 - 177
参考文献
Trans. Kentucky Acad., , vol. 17, p. 135,137
参考文献
Nippon Kagaku Zasshi, , vol. 75, p. 1180,1181
Chem.Abstr., , p. 10785
参考文献
Zhurnal Obshchei Khimii, , vol. 28, p. 2355,2358; engl. Ausg. S. 2393, 2395
Zhurnal Obshchei Khimii, , vol. 22, p. 1224,1226; engl. Ausg. S. 1269, 1
Engl. Ausg. S. 1269, 1270
反应条件
1.1: 2.5 h / 70 °C / Cooling with ice 2.1: AlCl3, aluminium chloride / anhydrous dichloroethane / 3 h / 80 °C / Cooling with ice 2.2: 20 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C 4.1: pyridinium tribromide / tetrahydrofuran / 0 °C / Reflux 5.1: (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole / tetrahydrofuran / 0.67 h / -55 - -45 °C / Inert atmosphere 5.2: -45 - 0 °C / Inert atmosphere 5.3: 20 °C View Scheme
参考文献
TEIJIN PHARMA LIMITED
Patent: US2012/46467 A1, 2012 ;
反应条件
1.1: 2.5 h / 70 °C / Cooling with ice 2.1: AlCl3, aluminium chloride / anhydrous dichloroethane / 3 h / 80 °C / Cooling with ice 2.2: 20 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme
参考文献
TEIJIN PHARMA LIMITED
Patent: US2012/46467 A1, 2012 ;
反应条件
nitric acid; acetic acid T=20°C; 1 h;
参考文献
Goyal, K. C.; Khosla, B. D.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 11 p. 1045
反应条件
AcONO2; acetic anhydride T=20°C; 1 h;
参考文献
Goyal, K. C.; Khosla, B. D.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 11 p. 1045
