反应条件
1: 1-carboxy-3-indanone; 1-(pyrrolidin-1-yl)methyl-1,2,3,4-tetrahydroisoquinoline With 4-(N,N-dimethlyamino)pyridine in dichloromethane T=0°C; 0.5 h; 2: dicyclohexyl-carbodiimide in dichloromethane
参考文献
China Pharmaceutical University; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Yangtze River Pharmaceutical Group Co., Ltd.
Patent: EP2045243 A1, 2009 ;
Location in patent: Page/Page column 8-9 ;
EP 2045243 A1