4-碘-2-甲基磺酰基嘧啶合成路线 （共 13 条）
反应条件
hydrogen iodide in water T=20°C; 8 h;
参考文献
Johns, Brian A.; Gudmundsson, Kristjan S.; Turner, Elizabeth M.; Allen, Scott H.; Samano, Vicente A.; Ray, John A.; Freeman, George A.; Boyd Jr., F. Leslie; Sexton, Connie J.; Selleseth, Dean W.; Creech, Katrina L.; Moniri, Kelly R.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2397 - 2411
反应条件
Bu3SnLi in tetrahydrofuran
参考文献
Tetrahedron, , vol. 50, # 1 p. 275 - 284
反应条件
pyridine 4 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/9889 A1, 2006 ;
Location in patent: Page/Page column 56 ;
WO 2006/009889 A1
反应条件
tetrabutyl ammonium fluoride; bis(acetato)bis(triphenylphosphine)palladium(0) in tetrahydrofuran T=20°C; 3 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/95455 A2, 2003 ;
Location in patent: Page/Page column 49 ;
反应条件
Bu3SnLi in tetrahydrofuran
参考文献
Tetrahedron, , vol. 50, # 1 p. 275 - 284
反应条件
1: 4-iodo-2-(methylsulfanyl)pyrimidine With isopropylmagnesium chloride in tetrahydrofuran T=0°C; Metallation; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=0°C; Formylation; 2 h;
参考文献
Lepretre; Turck; Ple; Knochel; Queguiner
Tetrahedron, 2000 , vol. 56, # 2 p. 265 - 273
反应条件
lithium N,N-tert-butyl(1-isopropyl)pentylamide 1.) THF, -100 deg C, 10 min, 2.) THF, -100 deg C, 60 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Ple, Nelly; Turck, Alain; Heynderickx, Arnault; Queguiner, Guy
Tetrahedron, 1998 , vol. 54, # 33 p. 9701 - 9710
反应条件
potassium fluoride; copper(l) iodide; 3-Iodopyridazine in N,N-dimethyl-formamide T=115°C; 10 h;
参考文献
Ple, N.; Turck, A.; Heynderickx, A.; Queguiner, G.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 2 p. 551 - 556
反应条件
1: 68 percent / copper(I) iodide, KF, iododiazine / dimethylformamide / 10 h / 115 °C 2: 1.) n-BuLi, 2,2,6,6-tetramethylpiperidine, 2.) hexachloroethane / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C, 2 h View Scheme
参考文献
Ple, N.; Turck, A.; Heynderickx, A.; Queguiner, G.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 2 p. 551 - 556
反应条件
1: 68 percent / copper(I) iodide, KF, iododiazine / dimethylformamide / 10 h / 115 °C
2: 1.) n-BuLi, 2,2,6,6-tetramethylpiperidine, 2.) hexachloroethane / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C, 2 h
View Scheme
参考文献
Ple, N.; Turck, A.; Heynderickx, A.; Queguiner, G.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 2 p. 551 - 556
