1: methanephosphonic acid dimethyl ester With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; Metallation; 0.0833333 h;
2: 1-dodecanal in tetrahydrofuran; hexane
T=-78°C; Addition; 0.0833333 h;
参考文献
Kawashima, Takayuki; Ishii, Takafumi; Inamoto, Naoki; Tokitoh, Norihiro; Okazaki, Renji
Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 1 p. 209 - 219
1: dimethyl lt;1-(methoxycarbonyl)ethylgt;phosphonate With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 40°C; Horner-Wadsworth-Emmons olefination;
2: 1-dodecanal in tetrahydrofuran; mineral oil
Horner-Wadsworth-Emmons olefination; 24 h; Reflux;
3: With platinum(IV) oxide; hydrogen in methanol
参考文献
Nawrath, Thorben; Gerth, Klaus; Mueller, Rolf; Schulz, Stefan
Chemistry and Biodiversity, 2010 , vol. 7, # 9 p. 2228 - 2253
