N-甲基-N-甲氧基胺盐酸盐合成路线 （共 166 条）
反应条件
triethylamine Acylation;
参考文献
Barrett, Anthony G. M.; Cramp, Susan M.; Roberts, Richard S.; Zecri, Frederic J.
Organic Letters, 2000 , vol. 2, # 3 p. 261 - 264
反应条件
4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide in dichloromethane T=0 - 25°C; 20.5 h;
参考文献
RICHTER GEDEON VEGYESZETI GYAR RT.
Patent: WO2007/39782 A1, 2007 ;
Location in patent: Page/Page column 23-24 ;
WO 2007/039782 A1
反应条件
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
PFIZER JAPAN INC.; PFIZER INC.
Patent: WO2008/32204 A1, 2008 ;
Location in patent: Page/Page column 37-38 ;
WO 2008/032204 A1
反应条件
isopropylmagnesium chloride in tetrahydrofuran T=-10 - 5°C; 2.5 h;
参考文献
Merck and Co., Inc.
Patent: US6369275 B1, 2002 ;
Location in patent: Page column 14-15 ;
反应条件
triethylamine Acylation;
参考文献
Barrett, Anthony G. M.; Cramp, Susan M.; Roberts, Richard S.; Zecri, Frederic J.
Organic Letters, 2000 , vol. 2, # 3 p. 261 - 264
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 20°C;
参考文献
Gopalsamy, Ariamala; Shi, Mengxiao; Bennett, Eric M.; Bard, Joel; Zhang, Wei-Guo; Yu, Ker
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6636 - 6641,6
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in pyridine; dichloromethane Condensation;
参考文献
Hulme, Christopher; Ma, Liang; Romano, Joseph; Morrissette, Matthew
Tetrahedron Letters, 1999 , vol. 40, # 45 p. 7925 - 7928
反应条件
(i) Py, CHCl3, (ii) /BRN= 906699/; Multistep reaction;
参考文献
Ludwig,B.J. et al.
Journal of Medicinal Chemistry, 1969 , vol. 12, # 3 p. 462 - 472
参考文献
Lee, Yun Suk; Kim, Hee; Kim, Young-Ho; Roh, Eun Joo; Han, Hogyu; Shin, Kye Jung
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7555 - 7561
反应条件
triethylamine in diethyl ether T=-20 - -10°C; 1 h;
参考文献
Chervin, I. I.; Nasibov, Sh. S.; Rudchenko, V. F.; Shtamburg, V. G.; Kostyanovskii, R. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 3 p. 389 - 396
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 3 p. 544 - 552
