1-(苯氧基甲基)-1H-苯并噻唑合成路线 （共 14 条）
反应条件
n-butyllithium; zinc dibromide
1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 4 h; -78 deg C to room temperature, overnight, 3.) CHCl2CHCl2, 140 deg C, 12 h; Yield given. Multistep reaction;
参考文献
Katritzky, Alan R.; Xie, Linghong; Serdyuk, Larisa
Journal of Organic Chemistry, 1996 , vol. 61, # 21 p. 7564 - 7570
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 20°C;
2: With acetic acid
T=80°C;
参考文献
Yamane, Motoki; Uera, Kazuyoshi; Narasaka, Koichi
Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 3 p. 477 - 486
反应条件
n-butyllithium in tetrahydrofuran
-78 deg C, 30 min then r.t., 10 h;
参考文献
Katritzky, Alan R.; Zhang, Zhongxing; Lang, Hengyuan; Xie, Linghong
Heterocycles, 1998 , vol. 47, # 1 p. 187 - 194
反应条件
1: 95 percent / n-BuLi / tetrahydrofuran; hexane / 12 h / -78 - 20 °C
2: 68 percent / benzene / 12 h / Heating
3: 78 percent / diethyl ether / 1) -78 deg C, 0.5 h; 2) rt, 48 h
View Scheme
参考文献
Katritzky, Alan R.; Wang, Jin; Karodia, Nazira; Li, Jianqing
Journal of Organic Chemistry, 1997 , vol. 62, # 12 p. 4142 - 4147
