1-苄基六氢-4H-氮杂烷-4-醇合成路线 （共 11 条）
反应条件
lithium aluminium tetrahydride in diethyl ether T=0°C; 1 h;
参考文献
EP1403255 A1, ;
Page 93 ;
EP 1403255 A1
反应条件
potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride in toluene; benzene
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 51, # 9 p. 2034 - 2049
反应条件
1: 91 percent / K2CO3 / CHCl3 / 7.5 h / Heating 2: 1) C2H5OK, 2) HCl / 1) ethanol, xylene, reflux, 16 h; 2) ethanol. 3: 92 percent / K2CO3, sodium dihydridobis(2-methoxyethoxo)aluminate / benzene; toluene View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 51, # 9 p. 2034 - 2049
反应条件
1: 94 percent / K2CO3 / CHCl3 / 7 h / Heating 2: 1) C2H5OK, 2) HCl / 1) ethanol, xylene, reflux; 2) ethanol. 3: 92 percent / K2CO3, sodium dihydridobis(2-methoxyethoxo)aluminate / benzene; toluene View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 51, # 9 p. 2034 - 2049
反应条件
1: 1) C2H5OK, 2) HCl / 1) ethanol, xylene, reflux; 2) ethanol. 2: 92 percent / K2CO3, sodium dihydridobis(2-methoxyethoxo)aluminate / benzene; toluene View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 51, # 9 p. 2034 - 2049
反应条件
1: 1) C2H5OK, 2) HCl / 1) ethanol, xylene, reflux, 16 h; 2) ethanol. 2: 92 percent / K2CO3, sodium dihydridobis(2-methoxyethoxo)aluminate / benzene; toluene View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 51, # 9 p. 2034 - 2049
反应条件
1: methanol; barium oxide 2: diethyl ether; lithium alanate View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 31, p. 418,420
反应条件
1: water; hydrochloric acid / Behandeln des Reaktionsprodukts mit wss. Natronlauge 2: methanol; barium oxide 3: diethyl ether; lithium alanate View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 31, p. 418,420
参考文献
Polivka, Zdenek; Metys, Jan; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 9 p. 2034 - 2049
反应条件
1: 1-benzyl-4-hydroxyhexahydro-1H-azepine With ammonium formate; palladium 10 on activated carbon in ethanol 1 h; Heating / reflux; 2: carbonic acid di-tert-butyl ester in dichloromethane T=20°C; 19 h;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1403255 A1, 2004 ;
Location in patent: Page 93-94 ;
EP 1403255 A1
