N,N-二甲基-3-氯丙胺合成路线 （共 146 条）
反应条件
(i) NaNH2, benzene, (ii) /BRN= 605294/; Multistep reaction;
参考文献
Pallos; Budai; Zolyomi
Arzneimittel-Forschung, 1972 , vol. 22, # 9 p. 1502 - 1505
反应条件
1: indole With sodium hydride in tetrahydrofuran; mineral oil T=0°C; 2: 1-dimethylamino-3-chloropropane in tetrahydrofuran; mineral oil Reflux;
参考文献
Hill, Timothy A.; Gordon, Christopher P.; McGeachie, Andrew B.; Venn-Brown, Barbara; Odell, Luke R.; Chau, Ngoc; Quan, Annie; Mariana, Anna; Sakoff, Jennette A.; Chircop, Megan; Robinson, Phillip J.; McCluskey, Adam
Journal of Medicinal Chemistry, 2009 , vol. 52, # 12 p. 3762 - 3773
反应条件
sodium hydroxide; potassium carbonate DMSO 1.) room temp., 2 h, 2.) 110 deg C, 18 h; Yield given. Multistep reaction;
参考文献
Schmolka; Zimmer
Synthesis, 1984 , vol. NO. 1, p. 29 - 31
反应条件
(i) NaOMe, benzene, (ii) /BRN= 605294/; Multistep reaction;
参考文献
Pelz,K. et al.
Collection of Czechoslovak Chemical Communications, 1968 , vol. 33, # 7 p. 2111 - 2120
反应条件
ammonium hydroxide; magnesium; acetic acid in tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
参考文献
H. Lundbeck, A/S
Patent: US6258842 B1, 2001 ;
反应条件
ammonium hydroxide; magnesium; acetic acid in tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
参考文献
H. Lundbeck, A/S
Patent: US6258842 B1, 2001 ;
反应条件
in tetrahydrofuran; diethyl ether addn. of tributyltin lithium soln. (prepared in situ from Li and (n-Bu)3SnCl in THF) at -7°C to soln. of the propane in dry ether, mixt.immediately turned white, stirred (2h), refluxed (1h); addn. of water, extd. with CH2Cl2, organic layer dried (MgSO4), evapn. (vac.), bulb to bulb distn. (120°C, 0.1 mmHg) of yellow liq., flash chromy. (Florisil, pentane), addn. of ethylacetate/hexane (2/5);
参考文献
Suggs, J. William; Lee, Ken. S.
Journal of Organometallic Chemistry, 1986 , vol. 299, p. 297 - 310
反应条件
sodium hydroxide; potassium carbonate DMSO 1.) room temp., 2 h, 2.) 110 deg C, 18 h; Yield given. Multistep reaction;
参考文献
Schmolka; Zimmer
Synthesis, 1984 , vol. NO. 1, p. 29 - 31
参考文献
Ahn, Gang; Schifano-Faux, Nadege; Goossens, Jean-Francois; Baldeyrou, Brigitte; Couture, Axel; Grandclaudon, Pierre; Lansiaux, Amelie; Ryckebusch, Adina
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2259 - 2263
参考文献
Knorr; Roth
Chemische Berichte, 1906 , vol. 39, p. 1425
